ArticleThe Journal of allergy and clinical immunology2020
B lymphocytes directly contribute to tissue fibrosis in patients with IgG
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Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78citing papers in PubMed
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Who cites it
78 citing papers in PubMed, 144 citations in OpenAlex.
- Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: A randomized controlled trial.The Journal of allergy and clinical immunology · 2023Trial
- Dense Plasma Cell Infiltrates Foster Stromal Desmoplasia and Immune Evasion in Oral Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Pathogenesis exploration of lgG4-related disease: From the traditional central dogma and its remodeling perspective.Chinese medical journal · 2026Review
- The Evolving Landscape of CAR T-Cell Therapy in Autoimmune Diseases: A State-of-the-Art Review (2025).Clinical reviews in allergy & immunology · 2026Review
- Immunological Biomarkers to Assess Activity and Treatment Response in IgG4-Related Disease.Medicina (Kaunas, Lithuania) · 2026Article
- Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- UPLC-MS/MS-based metabolomics analysis identifies disease-associated metabolic signatures of B cells from patients with IgG4-RD.Frontiers in immunology · 2026Article
- B cell receptor signaling in autoimmune rheumatic diseases: regulatory mechanisms and therapeutic targeting.Frontiers in immunology · 2026Review
- An intricate relationship between fibrosis and autoimmune diseases: a specific focus on unraveling its molecular, immunological, and epigenetic drivers.Frontiers in immunology · 2026Review
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- Targeting B cells in IgA nephropathy: from pathogenic insight to therapeutic horizon.Clinical kidney journal · 2025Article
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- IgG4-Related Cholangitis.Seminars in liver disease · 2025Review
- IgG4-Mediated Sclerosing Riedel Thyroiditis: A Multidisciplinary Case Study and Literature Review.International journal of molecular sciences · 2025Review
- Tertiary Lymphoid Structures in Tuberculosis: Persistence, Protection, and Pathology.Immunological reviews · 2025Review
- Omics in IgG4-related disease.Chinese medical journal · 2025Review
- Global research trends and emerging focus areas in IgG4-related disease: a bibliometric and visual analysis.Hereditas · 2025Article
- IgG4-related disease and other fibro-inflammatory conditions.Nature reviews. Rheumatology · 2025Review
- B cell depletion after treatment with rituximab predicts relapse of IgG4-related disease.Rheumatology (Oxford, England) · 2025Article
- Skin Deep and Beyond: Unravelling B Cell Extracellular Matrix Interactions in Cutaneous Immunity and Disease.Experimental dermatology · 2025Review
18 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 7 institutions in 4 countries.
Emanuel Della-TorreUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy; Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: dellatorre.emanuel@hsr.it.
Elena RigamontiUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cory PeruginoRagon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Simona Baghai-SainCenter for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Na SunRagon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Naoki KanekoRagon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Takashi MaeharaRagon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Lucrezia RovatiUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy; Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Maurilio PonzoniUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Raffaella MilaniImmunohematology and Transfusion Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Marco LanzillottaUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vinay MahajanRagon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Hamid MattooImmunology and Inflammation Therapeutic Area, Sanofi, Cambridge, Mass.
Ivan MolinerisCenter for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vikram DeshpandeDepartment of Pathology, Massachusetts General Hospital, Boston, Mass.
John H StoneDivision of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Massimo FalconiUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy; Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Angelo A ManfrediUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy; Unit of Immunology, Rheumatology, Allergy, and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Shiv PillaiRagon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Ragon Institute of MGH, MIT and Harvard · USIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleVita-Salute San Raffaele University · ITMassachusetts General Hospital · USKyushu University · JPSanofi (France) · FR
Funding
The importance of the IgG4 glycome in IgG4-related disease(s)U19AI110495 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 2014 to 2026
$7.9MResearch Training in Rheumatology at Massachusetts General HospitalT32AR007258 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1986 to 2026
$6.9MPathogenesis of IgG4 related diseaseK08AI113163 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MAHAJAN, VINAY SUBHASH · 2014 to 2018
$953kNIAID NIH HHS K08 AI113163NIAID NIH HHS U19 AI110495NIAMS NIH HHS T32 AR007258
Abstract
backgroundIgG
objectiveIn the present work we aimed to demonstrate that B lymphocytes contribute directly to tissue fibrosis in patients with IgG
methodsTotal circulating CD19
resultsB cells from patients with IgG
conclusionWe have demonstrated that B cells contribute directly to tissue fibrosis in patients with IgG
Indexed as
B-LymphocytesCells, CulturedCoculture TechniquesCollagenFibroblastsFibrosisHumansImmunoglobulin G4-Related DiseasePancreasCollagenB cellsfibroblastsfibrosisIgG(4)IgG(4)-related diseaselysyl oxidase homolog 2plasmablastsplatelet-derived growth factorrituximab
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.