Evidence map›Paper›PMID 31319045›Full record

ArticleNeuron2019

How to Break a Fever: A Feedback Circuit for Body Temperature Control.

Bo Duan, X Z Shawn Xu

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bo DuanDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: bduan@umich.edu.
X Z Shawn XuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: shawnxu@umich.edu.
University of Michigan · US

Funding

Neural and genetic mechanisms underlying behavior in C. elegans - Administrative Supplement for Equipment PurchasesR35GM126917 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2018 to 2025
$3.3M
Dissecting neural circuits for mechanical itchR01NS109170 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO · 2019 to 2023
$2.2M
Thermosensation and longevity in C. elegansR01AG048072 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2014 to 2018
$1.6M
NIA NIH HHS R01 AG048072NIGMS NIH HHS R35 GM126917NINDS NIH HHS R01 NS109170
6 · The paper itself

Abstract

Body temperature control is a critical brain function. In this issue of Neuron, Wang et al. identify a negative feedback circuit in mouse preoptic area of the hypothalamus that regulates body temperature to counter fever.

Indexed as

Preoptic AreaProstaglandin D2AnimalsBody Temperature RegulationFeverHypothalamusMiceTemperatureProstaglandin D2

Identifiers

PMID31319045
PMCPMC6692133
OpenAlexW2957693593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.