ArticleInternational journal of cancer2020
Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.
Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Hypertension and risk of cancer recurrence in adult survivors: A systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- Pooled it
- High incidence of colorectal cancer in Japanese individuals with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Urolithiasis in patients with cancer.Nature reviews. Urology · 2026Review
- Dual-trajectories of Systolic Blood Pressure and Modified Life's Essential 8 With Gastrointestinal Cancer and All-Cause Mortality: A Prospective Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Hypertension-cancer recurrence crosstalk: implications for survivorship care.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The Association Between Religiosity and Lifelong Cancer Incidence in an Israeli Male Cohort: A Competing Risk Survival Analysis.Epidemiologia (Basel, Switzerland) · 2026Article
- Lowering Blood Pressure, Raising Cancer Risk?: Evidence From Randomized Clinical Trials and Genetic Studies.JACC. CardioOncology · 2025Article
- Blood Pressure Lowering and Risk of Cancer: Individual Participant-Level Data Meta-Analysis and Mendelian Randomization Studies.JACC. CardioOncology · 2025Article
- Changes in the Characteristics of Kidney Cancer Detection During the COVID-19 Pandemic.Cancers · 2025Article
- Cancer screening and its associated factors in hypertensive individuals: new insights from the 2021 STEPs national study in Iran.BMC public health · 2025Article
- Life's essential 8 and specific cancer risk and mortality in men and women: a population-based cohort analysis of 332,417 United Kingdom participants.BMC cancer · 2025Article
- Changes in blood pressure and metabolic factors of patients after esophagectomy assessed based on a propensity score matching approach.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- Reviewing the path to balance: mechanisms and management of hypertension associated with targeting vascular endothelium in cancer therapy.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Smoking cessation is a protective factor for lung cancer onset and mortality: a population-based prospective cohort study.BMC cancer · 2025Article
- Associations between cardiometabolic comorbidities and mortality in adults with cancer: multinational cohort study.BMJ medicine · 2025Article
- Current Status and Future Perspective of Onco-Hypertension.American journal of hypertension · 2024Review
- Associations between the life's essential 8, genetic risk and breast cancer incidence in premenopausal and postmenopausal women: a prospective study in UK Biobank.Medical oncology (Northwood, London, England) · 2024Article
- Analysis of the epidemiological trends and spatial patterns of esophageal cancer among male populations in China's mainland from 1990 to 2021.Thoracic cancer · 2024Article
- Association of Life's Essential 8 cardiovascular health with breast cancer incidence and mortality according to genetic susceptibility of breast cancer: a prospective cohort study.Breast cancer research : BCR · 2024Article
Corrections and comments
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Authors and funding
48 authors at 20 institutions in 13 countries.
Funding
Abstract
Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP), HR = 1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04-1.12) (SBP), HR = 1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82-1.00) and lymphomas: HR = 0.97 (0.93-1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.
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Registered trials
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