ArticleHepatology (Baltimore, Md.)2020
A Metallomic Approach to Assess Associations of Serum Metal Levels With Gallstones and Gallbladder Cancer.
Article in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Carcinogenic effect of arsenic in digestive cancers: a systematic review.Environmental health : a global access science source · 2023Pooled it
- The role of copper and cuproptosis in digestive system cancers: novel therapeutic strategies and mechanistic insights.Cancer biology & therapy · 2026Review
- Association between oxidative balance score and gallstone risk and gallbladder surgery: A cross-sectional study.The Journal of international medical research · 2026Article
- Association between urinary cadmium levels and increased gallstone disease in US adults.Scientific reports · 2025Article
- Global variations in gallbladder cancer incidence: What do recorded data and national estimates tell us?International journal of cancer · 2025Article
- The role of marital status in gallbladder cancer: a real-world competing risk analysis.BMC gastroenterology · 2024Article
- Risk Factors and Prognostic Factors in GBC.Journal of clinical medicine · 2024Review
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- The correlation between urinary iodine levels and gallstone risk: elevated iodine intake linked to gallstone occurrence.Frontiers in nutrition · 2024Article
- Phthalate and gallstones: the mediation of insulin.Frontiers in public health · 2024Article
- Trace elements in hair or fingernail and gastroesophageal cancers: results from a population-based case-control study.Journal of exposure science & environmental epidemiology · 2023Article
- Epidemiological trends of gallbladder cancer in Australia between 1982 to 2018: A population-based study utilizing the Australian Cancer Database.Annals of hepato-biliary-pancreatic surgery · 2022Article
- Mutational signatures and processes in hepatobiliary cancers.Nature reviews. Gastroenterology & hepatology · 2022Review
- Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer.Journal of personalized medicine · 2022Review
- Article
- The Chile Biliary Longitudinal Study: A Gallstone Cohort.American journal of epidemiology · 2021Article
- A transcriptome profile in gallbladder cancer based on annotation analysis of microarray studies.Molecular medicine reports · 2021Article
- Disease Ionomics: Understanding the Role of Ions in Complex Disease.International journal of molecular sciences · 2020Review
- Possibility of magnesium supplementation for supportive treatment in patients with COVID-19.European journal of pharmacology · 2020Review
- Cadmium exposure activates Akt/ERK Signaling and pro-inflammatory COX-2 expression in human gallbladder epithelial cells via a ROS dependent mechanism.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
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Authors and funding
11 authors at 9 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
aimsExposure to metals may promote the risk for cancers. We evaluated the associations of a broad spectrum of metals with gallbladder cancer (GBC) and gallstones. APPROACH AND
resultsA total of 259 patients with GBC, 701 patients with gallstones, and 851 population-based controls were enrolled in Shanghai, China. A metallome panel was used to simultaneously detect 18 metals in serum through inductively coupled plasma-mass spectrometry. Logistic regression models were used to estimate crude or adjusted odds ratios (OR
conclusionsMetals were associated with both GBC and gallstones, providing cross-sectional evidence of association across the natural history of disease. Longitudinal studies are needed to evaluate the temporality of metal exposure and gallbladder diseases and to investigate the mechanisms of disease pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.