ArticlePloS one2019
Health risks associated with social isolation in general and in young, middle and old age.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
94 citing papers in PubMed, 4 syntheses or guidelines pooled it, 232 citations in OpenAlex.
- Social Isolation and Loneliness in People Living With Chronic Kidney Disease and Kidney Failure: A Mixed Method Systematic Review.Journal of renal care · 2026Pooled it
- Psychometric Validation of a Combined Assessment for Anxiety and Depression in Primary Care in Mozambique (CAD-MZ).Assessment · 2022Pooled it
- Effects of Objective and Perceived Social Isolation on Cardiovascular and Brain Health: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2022Pooled it
- Interventions to improve social connections: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2022Pooled it
- Feasibility of Using a Wearable Device to Identify Loneliness Among Older Adults Living Alone: Mixed Methods Study.JMIR formative research · 2026Article
- Social isolation and overall well-being among cancer survivors in the Cancer Prevention Study-3.Journal of cancer survivorship : research and practice · 2026Article
- Examining associations of social disconnectedness change patterns with subsequent healthcare utilization and costs among public healthcare users in Central Singapore.Scientific reports · 2026Article
- Development and validation of the Korea University Social Isolation Scale.BMC public health · 2026Article
- Chronic disease and social isolation among Canadians: evidence from the 2022 Mental Health and Access to Care Survey.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2026Article
- Social isolation of aged mice drives dramatic release of inflammatory lipoxygenase-derived oxylipins.npj aging · 2026Article
- Social isolation in mid-life: associations with psychological distress, life satisfaction and self-rated health in two successive British birth cohorts.Social psychiatry and psychiatric epidemiology · 2026Article
- The influence of social support on pain, symptom severity, and quality of life in fibromyalgia.Turkish journal of physical medicine and rehabilitation · 2026Article
- Patient-Reported Characteristics and Care-Seeking among Canadian Adults with Chronic Pain: An Online Cross-Sectional Survey.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- Article
- Overindebted, unsupported and lonely, and mentally stressed and depressed-exploring the relationship between overindebtedness, social disconnectedness and poor mental health in a population-based Swiss study.BMC public health · 2025Article
- Article
- Associations of social isolation with memory and cognitive function in middle-aged and older Chinese adults.Aging clinical and experimental research · 2025Article
- Physical Activity and Neurocognitive Symptoms in Older Adults During COVID-19 Pandemic.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Creation and verification of a predictive nomogram model for the incidence of social isolation among China's older population.Frontiers in public health · 2025Article
- Social disconnectedness, economic outcomes, and the role of pre-existing mental health conditions: A population-based cohort study.PLOS mental health · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHealth effects of social isolation are well-studied at older age, in English-speaking countries, for individual health conditions, and based on unidimensional measures of isolation. Hardly any evidence exists for younger ages, for continental European and particularly German-speaking countries and based on multidimensional measures of isolation. This study therefore aimed to examine prevalence rates and associations of social isolation with various health conditions and behaviors in the entire Swiss population and across different age groups.
methodsNationally representative cross-sectional data from the Swiss Health Survey collected in 2012 were used and analyzed. The study sample covered 21,597 randomly selected adolescents and adults living in Switzerland and aged 15 and older. A multifactorial five-item social integration index was used to assess social disconnectedness and perceived isolation.
resultsSocial isolation has been found to steadily increase with age and almost consistently to be strongly associated with poor health conditions and unfavorable behaviors across all ages. Nearly a quarter of the general population could be categorized as either only partly integrated or even poorly integrated and largely isolated. The socially isolated people independent of their age showed strongly elevated relative risks of poor self-rated health (aOR = 4.0), musculoskeletal disorders (aOR = 2.8), moderate to severe depression (aOR = 11.5), and multiple health problems (aOR = 5.0). They were also found to be at comparably high risk of behaving unhealthy with regard to physical inactivity (aOR = 2.2), poor diet (aOR = 1.9) and use of psychotropic medications (aOR = 3.6). Although prevalence rates of poor health conditions and behaviors differed greatly between the studied age groups, strong associations and clear dose-response relationships have been found separately for all age groups and particularly for the youngest. A fairly weak or no association at all (depending on the age group) with the degree of social integration was observed only for daily smoking.
conclusionsSocial isolation may be less prevalent at younger ages, but is then even more strongly associated with poor health conditions and behaviors than at older ages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.