Evidence map›Paper›PMID 31318619›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019

Exogenous neuromodulation of spinal neurons induces beta-band coherence during self-sustained discharge of hind limb motor unit populations.

Christopher K Thompson, Michael D Johnson, Francesco Negro, Laura Miller Mcpherson, Dario Farina, Charles J Heckman

Open access · bronzeAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Reading and Modulating Cortical β Bursts from Motor Unit Spiking Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Christopher K ThompsonDepartment of Physical Therapy, Temple University, Philadelphia, Pennsylvania.
Michael D JohnsonDepartment of Physiology, Northwestern University, Evanston, Illinois.
Francesco NegroDepartment of Clinical and Experimental Sciences, Research Centre for Neuromuscular Function and Adapted Physical Activity "Teresa Camplani," Università degli Studi di Brescia, Bescia, Italy.ORCID 0000-0002-9094-8932
Laura Miller McphersonDepartment of Physical Therapy, Florida International University, Miami, Florida.ORCID 0000-0001-8228-0525
Dario FarinaDepartment of Bioengineering, Imperial College London, London, United Kingdom.ORCID 0000-0002-7883-2697
Charles J HeckmanDepartment of Physiology, Northwestern University, Evanston, Illinois.
Northwestern University · USFlorida International University · USImperial College London · GBTemple University · USUniversity of Brescia · IT

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
PATHOPHYSIOLOGY AND REHABILITATION OF NEURAL DYSFUNCTIONT32HD007418 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Levi John Hargrove · 1992 to 2026
$6.5M
Mechanisms of electrical stimulation of a canonical motor microcircuitR01NS109552 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2018 to 2022
$2.5M
Interdisciplinary Graduate Education in Movement and Rehabilitation Sciences-RenewalT32EB009406 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JULIUS P DEWALD, JUN YAO · 2009 to 2026
$2.2M
Reverse Engineering Motor Unit Discharge PatternsR01NS085331 · NINDS · UNIVERSITY OF WASHINGTON · PI HECKMAN, CHARLES, POWERS, RANDALL K · 2014 to 2018
$1.7M
European Research CouncilNCATS NIH HHS UL1 TR001422NIBIB NIH HHS T32 EB009406NICHD NIH HHS T32 HD007418NINDS NIH HHS R01 NS085331NINDS NIH HHS R01 NS109552
6 · The paper itself

Abstract

The spontaneous or self-sustained discharge of spinal motoneurons can be observed in both animals and humans. Although the origins of this self-sustained discharge are not fully known, it can be generated by activation of persistent inward currents intrinsic to the motoneuron. If self-sustained discharge is generated exclusively through this intrinsic mechanism, the discharge of individual motor units will be relatively independent of one another. Alternatively, if increased activation of premotor circuits underlies this prolonged discharge of spinal motoneurons, we would expect correlated activity among motoneurons. Our aim is to assess potential synaptic drive by quantifying coherence during self-sustained discharge of spinal motoneurons. Electromyographic activity was collected from 20 decerebrate animals using a 64-channel electrode grid placed on the isolated soleus muscle before and following intrathecal administration of methoxamine, a selective α

Indexed as

AnimalsCatsFemaleHindlimbMaleMotor NeuronsMuscle, SkeletalSpinecatcoherencemotoneuronmotor unitneuromodulation

Identifiers

PMID31318619
PMCPMC6850985
OpenAlexW2963610053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.