Evidence map›Paper›PMID 31318566›Full record

ArticleMolecular pharmaceutics2019

Enhancing the Efficacy of Melanocortin 1 Receptor-Targeted Radiotherapy by Pharmacologically Upregulating the Receptor in Metastatic Melanoma.

Mengshi Li, Dijie Liu, Dongyoul Lee, Somya Kapoor, Katherine N Gibson-Corley, Thomas P Quinn, Edwin A Sagastume, Sarah L Mott, Susan A Walsh, Michael R Acevedo and 2 more

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Picolinamide-functionalized macrocyclic chelators forInorganic chemistry frontiers · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. EJNMMI radiopharmacy and chemistry · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Signaling Network Response to α-Particle-Targeted Therapy with theJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. [MC1R is highly expressed in esophageal squamous cell carcinoma].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Current issues in molecular biology · 2021
    Article
  19. Review
  20. Application of Phage-Displayed Peptides in Tumor Imaging Diagnosis and Targeting Therapy.International journal of peptide research and therapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mengshi Li
Dijie Liu
Dongyoul Lee
Somya Kapoor
Katherine N Gibson-Corley
Thomas P QuinnDepartment of Biochemistry , University of Missouri , Columbia , Missouri 65211 , United States.ORCID 0000-0001-5352-5335
Edwin A SagastumeViewpoint Molecular Targeting, Inc. , Coralville , Iowa 52241 , United States.
Sarah L Mott
Susan A Walsh
Michael R Acevedo
Frances L JohnsonViewpoint Molecular Targeting, Inc. , Coralville , Iowa 52241 , United States.
Michael K SchultzViewpoint Molecular Targeting, Inc. , Coralville , Iowa 52241 , United States.ORCID 0000-0002-4554-2212
University of Iowa · USViewpoint Molecular Targeting (United States) · USUniversity of Missouri · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Project 4: New Approaches to Improving the Effectiveness of Radionuclide Targeted Treatments in Neuroendocrine TumorsP50CA174521 · NCI · UNIVERSITY OF IOWA · PI ODORISIO, THOMAS · 2015 to 2021
$13.2M
Mitochondrial Targeted Metastatic Melanoma TherapyK25CA172218 · NCI · UNIVERSITY OF IOWA · PI SCHULTZ, MICHAEL KING · 2013 to 2017
$753k
Request for Funds to Purchase a Replacement Laser Scanning Confocal MicroscopeS10RR025439 · NCRR · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2009 to 2009
$500k
Pannoramic 250 BF Flash Tissue Microarray systemS10OD016355 · OD · VANDERBILT UNIVERSITY · PI BOYD, KELLI L. · 2014 to 2014
$453k
Production of Image-Guided Metastatic Melanoma Therapy RadiopharmaceuticalsR43CA203430 · NCI · VIEWPOINT MOLECULAR TARGETING, INC. · PI JOHNSON, FRANCES L · 2016 to 2017
$349k
Image guided therapy for metastatic melanomaR43CA195925 · NCI · VIEWPOINT MOLECULAR TARGETING, INC. · PI JOHNSON, FRANCES L · 2015 to 2015
$150k
NCI NIH HHS K25 CA172218NCI NIH HHS P30 CA086862NCI NIH HHS P50 CA174521NCI NIH HHS R43 CA195925NCI NIH HHS R43 CA203430NCRR NIH HHS S10 RR025439NIH HHS S10 OD016355
6 · The paper itself

Abstract

Melanocortin 1 receptor (MC1R) is under investigation as a target for drug delivery for metastatic melanoma therapy and imaging. The purpose of this study was to determine the potential of using BRAF inhibitors (BRAF

Indexed as

Alpha ParticlesAnimalsCell Line, TumorCombined Modality TherapyDrug Delivery SystemsFemaleHistone Deacetylase InhibitorsHumansImidazolesLead RadioisotopesMelanomaMice, NudeMicrophthalmia-Associated Transcription FactorOximesPhenylbutyratesPilot Projects4-phenylbutyric acidBRAF protein, humandabrafenibHistone Deacetylase InhibitorsImidazolesLead-212Lead RadioisotopesMC1R protein, humanMicrophthalmia-Associated Transcription FactorMITF protein, humanOximesPhenylbutyratesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafReceptor, Melanocortin, Type 1BRAF inhibitorshistone deacetylase inhibitorsMAPK pathway inhibitorsMEK inhibitorsmelanocortin 1 receptormelanomaradionuclide therapy

Identifiers

PMID31318566
PMCPMC6765223
OpenAlexW2962799181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.