Evidence map›Paper›PMID 31318538›Full record

ArticleBiochemistry2019

Mechanism of Single-Stranded DNA Activation of Recombinase Intein Splicing.

Christopher W Lennon, Matthew J Stanger, Marlene Belfort

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Conditional protein splicing of thebioRxiv : the preprint server for biology · 2024
    Article
  6. A Chemical Biology Primer for NMR Spectroscopists.Journal of magnetic resonance open · 2022
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher W LennonDepartment of Biological Sciences and RNA Institute and Department of Biomedical Sciences, School of Public Health , University at Albany , Albany , New York 12222 , United States.ORCID 0000-0001-9413-180X
Matthew J StangerDepartment of Biological Sciences and RNA Institute and Department of Biomedical Sciences, School of Public Health , University at Albany , Albany , New York 12222 , United States.
Marlene BelfortDepartment of Biological Sciences and RNA Institute and Department of Biomedical Sciences, School of Public Health , University at Albany , Albany , New York 12222 , United States.
University at Albany, State University of New York · US

Funding

SELF-SPLICING INTEINS: FUNCTION, EVOLUTION, APPLICATIONR01GM044844 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1990 to 2019
$8.9M
SELF-SPLICING INTRONS IN THE PHAGE T4/E COLI SYSTEMR01GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1988 to 2019
$5.3M
INTRON DYNAMICS IN BACTERIAR37GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 2001 to 2010
$4.0M
Post-translational regulation of recombinase function by intein splicingF32GM121000 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LENNON, CHRISTOPHER WILLIAM · 2016 to 2017
$119k
NIGMS NIH HHS F32 GM121000NIGMS NIH HHS R01 GM039422NIGMS NIH HHS R01 GM044844NIGMS NIH HHS R37 GM039422
6 · The paper itself

Abstract

Inteins, or intervening proteins, are mobile genetic elements translated within host polypeptides and removed through protein splicing. This self-catalyzed process breaks two peptide bonds and rejoins the flanking sequences, called N- and C-exteins, with the intein scarlessly escaping the host protein. As these elements have traditionally been viewed as purely selfish genetic elements, recent work has demonstrated that the conditional protein splicing (CPS) of several naturally occurring inteins can be regulated by a variety of environmental cues relevant to the survival of the host organism or crucial to the invading protein function. The RadA recombinase from the archaeon

Indexed as

RNA SplicingDNA, Single-StrandedInteinsPyrococcus horikoshiiRecombinasesDNA, Single-StrandedRecombinases

Identifiers

PMID31318538
PMCPMC8409432
OpenAlexW2963335325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.