Evidence map›Paper›PMID 31318497›Full record

ArticleObesity (Silver Spring, Md.)2019

BMI, Waist Circumference, and Risk of Incident Vertebral Fracture in Women.

Julie M Paik, Harold N Rosen, Jeffrey N Katz, Bernard A Rosner, Eric B Rimm, Catherine M Gordon, Gary C Curhan

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The association between overweight/obesity and vertebral fractures in older adults: a meta-analysis of observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  2. Muscle mass, not fat mass, predicts vertebral fracture risk: Vietnam osteoporosis study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  3. Article
  4. Muscle mass, not fat mass, predicts vertebral fracture risk: Vietnam osteoporosis study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Julie M PaikChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1315-5445
Harold N RosenHarvard Medical School, Harvard University, Boston, Massachusetts, USA.
Jeffrey N KatzDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Bernard A RosnerChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Eric B RimmChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Catherine M GordonHarvard Medical School, Harvard University, Boston, Massachusetts, USA.
Gary C CurhanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Acid-Base Status as a Novel Risk Factor for FracturesR01AR075117 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PAIK, JULIE · 2019 to 2024
$3.9M
Sex-related differences in incidence rates of nephrolithiasisK24DK091417 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CURHAN, GARY C. · 2011 to 2020
$1.5M
Novel Risk Factors for Vertebral Fractures in Health and Chronic Kidney DiseaseK23DK100447 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI PAIK, JULIE · 2013 to 2017
$938k
NCI NIH HHS UM1 CA186107NIAMS NIH HHS R01 AR075117NIDDK NIH HHS K23 DK100447NIDDK NIH HHS K24 DK091417
6 · The paper itself

Abstract

objectiveThe study aimed to investigate the association between BMI, waist circumference, and vertebral fracture (VF) risk in women.

methodsThis prospective study was conducted in 54,934 Nurses' Health Study participants. BMI was assessed biennially, and waist circumference was assessed in the year 2000. Self-reports of VF were confirmed by record review. BMI reflects lean body mass, and waist circumference reflects abdominal adiposity when included in the same regression model.

resultsThis study included 536 VF cases (2002 to 2014). Compared with women with BMI of 21.0 to 24.9 kg/m

conclusionsGreater lean body mass was independently associated with lower VF risk. Larger waist circumference was independently associated with higher VF risk. These findings suggest that fat distribution is an important predictor of VF and that avoiding central adiposity, as well as maintaining muscle mass, may potentially confer reduced risk of VF in older women.

Indexed as

Body Mass IndexSpinal FracturesWaist CircumferenceAgedCohort StudiesFemaleHumansProspective StudiesRisk Factors

Identifiers

PMID31318497
PMCPMC6707901

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.