ArticleCancer cytopathology2019
Cytologic features of upper gynecologic tract adenocarcinomas exhibiting mesonephric-like differentiation.
Article in Cancer cytopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Mesonephric-Like Adenocarcinoma of the Endometrium: A Rare and Diagnostically Challenging Entity.Cureus · 2026Article
- Ovarian cancer.Nature reviews. Disease primers · 2026Review
- Mesonephric-like adenocarcinoma of the uterine corpus: a case report.Frontiers in medicine · 2026Article
- Mesonephric-Like Adenocarcinoma of the Endometrium and the Impact of the Updated 2023 FIGO Staging System.Case reports in obstetrics and gynecology · 2026Article
- Cytopathologic features of mesonephric-like adenocarcinoma in the endometrium and ovary: eight cases and literature review.Virchows Archiv : an international journal of pathology · 2025Article
- Anti-GBM Disease Following Ovarian Mesonephric-Like Adenocarcinoma: A Unique Insight Into Paraneoplastic Autoimmunity.Kidney medicine · 2025Article
- Two Cases of Mesonephric-Like Adenocarcinoma Arising From Ovary and Peritoneal and Literature Review.Cureus · 2025Article
- Collision Tumor of the Ovary: Adult Granulosa Cell Tumor and Mesonephric-like Adenocarcinoma.Diagnostics (Basel, Switzerland) · 2024Article
- Case report: The first known case of male retroperitoneal mesonephric-like adenocarcinoma.Frontiers in oncology · 2024Article
- Mesonephric-like adenocarcinoma arising from endometrioid adenofibroma in a patient with in-utero exposure to diethylstilbestrol: A case report.Case reports in women's health · 2023Article
- Mesonephric-like Adenocarcinoma of the Ovary: Clinicopathological and Molecular Characteristics.Diagnostics (Basel, Switzerland) · 2022Article
- Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Immunohistochemical Analyses Using Markers for Mesonephric, Endometrioid and Serous Tumors.Diagnostics (Basel, Switzerland) · 2021Article
- Mesonephric-like Differentiation of Endometrial Endometrioid Carcinoma: Clinicopathological and Molecular Characteristics Distinct from Those of Uterine Mesonephric-like Adenocarcinoma.Diagnostics (Basel, Switzerland) · 2021Article
- The similarities and differences between mesonephric carcinoma and mesonephric-like carcinoma: Two cases.Gynecologic oncology reports · 2021Article
- Mesonephric-like adenocarcinoma of the ovary: A case report and a review of the literature.Medicine · 2020Review
- Atypical Mesonephric Hyperplasia of the Uterus Harbors Pathogenic Mutation of Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (Cancer genomics & proteomicsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundMesonephric adenocarcinomas are rare neoplasms which most commonly arise in the lateral cervix and vagina. Tumors with similar morphologic, immunophenotypic, and molecular characteristics recently have been described in the uterine corpus and ovary. Herein, the authors sought to characterize the cytomorphologic features of adenocarcinomas exhibiting mesonephric-like differentiation arising in the upper gynecologic tract.
methodsInstitutional databases were queried retrospectively for tumors of the upper gynecologic tract described as a "tumor of Wolffian origin" or "with mesonephric features" between 2007 and 2017. All available cytologic material was reviewed. Cytomorphologic characteristics were evaluated by 3 pathologists.
resultsThe current study cohort consisted of 8 cases taken from 7 patients. Primary sites included the ovary (3 cases); endometrium (4 cases); and pelvis, not otherwise specified (1 case). All cases demonstrated tight 3-dimensional clusters of overlapping cells. Additional architectural features included tubular (5 of 8 cases; 63%) and papillary (3 of 8 cases; 38%) formations. Cells were small with scant (7 of 8 cases; 88%) to moderate (1 of 8 cases; 12%) cytoplasm. Three of the 8 cases (38%) demonstrated extracellular hyaline globules. Nuclei were uniform in size (6 of 8 cases; 75%) or showed mild anisonucleosis (2 of 8 cases; 25%). Nuclear grooves and indentations were observed in all cases. Mitoses (5 of 8 cases; 63%) and apoptotic bodies (4 of 8 cases; 50%), when present, were rare. No necrosis was noted.
conclusionsAdenocarcinomas exhibiting mesonephric-like differentiation show a monotonous population of small cells with scant to moderate cytoplasm and abundant nuclear grooves arranged in tight, overlapping, 3-dimensional clusters. Occasionally, papillary or tubular architecture, as well as extracellular hyaline globules, may be seen. These features should prompt further testing (eg, immunohistochemistry) to confirm the diagnosis and to exclude potential mimics.
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