Evidence map›Paper›PMID 31318361›Full record

ArticleJournal of ophthalmology2019

Repressed Wnt Signaling Accelerates the Aging Process in Mouse Eyes.

Yujin Zhang, Joseph Jeffrey, Fei Dong, Jianhua Zhang, Winston W-Y Kao, Chia-Yang Liu, Yong Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yujin ZhangSchool of Optometry, Indiana University, 800 East Atwater Avenue, Bloomington, IN 47405, USA.
Joseph JeffreyCrawley Vision Research Laboratory, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Fei DongCrawley Vision Research Laboratory, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Jianhua ZhangCrawley Vision Research Laboratory, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Winston W-Y KaoCrawley Vision Research Laboratory, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Chia-Yang LiuSchool of Optometry, Indiana University, 800 East Atwater Avenue, Bloomington, IN 47405, USA.ORCID https://orcid.org/0000-0002-8398-5516
Yong YuanCrawley Vision Research Laboratory, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.ORCID https://orcid.org/0000-0003-0545-7459
University of Cincinnati · USIndiana University Bloomington · US

Funding

Roles of Growth Factors on Corneal MorphogenesisR01EY013755 · NEI · UNIVERSITY OF CINCINNATI · PI KAO, WINSTON W · 2002 to 2013
$4.0M
Molecular mechanism of corneal epithelial stratification and innervationR01EY029071 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2019 to 2022
$2.1M
NEI NIH HHS R01 EY013755NEI NIH HHS R01 EY029071
6 · The paper itself

Abstract

purposeOcular aging is a natural process of functional decline in vision. When the process reaches a point that compromised vision affects normal daily activity, it manifests as age-related ocular diseases, such as age-related macular degeneration, cataracts, glaucoma, and pseudoexfoliation syndrome. We previously reported that repressed Wnt signaling accelerated the maturation of corneal epithelium during tissue development. Here, we explore the hypothesis that repressed Wnt signaling is associated with accelerated aging in mouse eyes.

methodsWnt ligand antagonist secreted frizzled-related protein 1 (sFRP1) was expressed in the corneal stroma by a tissue-specific, inducible, bitransgenic system. Tissue structure was analyzed for signs of aging. Signal transduction analysis was performed to determine the cellular response to sFRP1.

resultsMouse eyes with sFRP1 expression showed signs of accelerated aging, resembling those found in pseudoexfoliation (PEX) syndrome, a known age-related disease. Specific findings include granular deposition on the surface of the anterior lens capsule, pigment loss from the anterior surface of the iris, the presence of fibrillary material in the anterior chamber, and changes in cell size (polymegethism) and shape (pleomorphism) of the corneal endothelial cells.

conclusionThe expression of sFRP1 accelerates the aging process in mouse eyes and future studies are warranted to elucidate the underlying mechanisms.

Identifiers

PMID31318361
PMCPMC6604355
OpenAlexW2949348041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.