Evidence map›Paper›PMID 31318326›Full record

ArticleMolecular biology of the cell2019

The Crk adapter protein is essential for

Andrew J Spracklen, Emma M Thornton-Kolbe, Alison N Bonner, Alexandru Florea, Peter J Compton, Rodrigo Fernandez-Gonzalez, Mark Peifer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Crk adaptor proteins are necessary for the development of the zebrafish retina.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Andrew J SpracklenLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Emma M Thornton-KolbeDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Alison N BonnerDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Alexandru FloreaInstitute of Biomaterials and Biomedical Engineering, Ted Rogers Centre for Heart Research, and Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5G 1M1, Canada.
Peter J ComptonDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Rodrigo Fernandez-GonzalezInstitute of Biomaterials and Biomedical Engineering, Ted Rogers Centre for Heart Research, and Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5G 1M1, Canada.
Mark PeiferLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
University of North Carolina at Chapel Hill · USTed Rogers Centre for Heart Research · CAUniversity of Toronto · CA

Funding

Integrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7M
Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesisR35GM118096 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark A. Peifer · 2016 to 2026
$6.5M
Defining how Abelson Kinase Regulates Cell Adhesion and Actin DynamicsF32GM117803 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SPRACKLEN, ANDREW J · 2016 to 2017
$116k
CIHR 156279NCI NIH HHS T32 CA009156NIGMS NIH HHS F32 GM117803NIGMS NIH HHS R35 GM118096
6 · The paper itself

Abstract

Small Src homology domain 2 (SH2) and 3 (SH3) adapter proteins regulate cell fate and behavior by mediating interactions between cell surface receptors and downstream signaling effectors in many signal transduction pathways. The CT10 regulator of kinase (Crk) family has tissue-specific roles in phagocytosis, cell migration, and neuronal development and mediates oncogenic signaling in pathways like that of Abelson kinase. However, redundancy among the two mammalian family members and the position of the

Indexed as

ActinsAdaptor Proteins, Signal TransducingAnimalsCell DifferentiationCell MovementCytoskeletonDrosophila melanogasterDrosophila ProteinsEmbryonic DevelopmentMorphogenesisOncogene Protein v-crkProto-Oncogene Proteins c-crkSignal Transductionsrc Homology DomainsActinsAdaptor Proteins, Signal TransducingDrosophila ProteinsOncogene Protein v-crkProto-Oncogene Proteins c-crk

Identifiers

PMID31318326
PMCPMC6741062
OpenAlexW2963688057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.