ArticleJournal of clinical hypertension (Greenwich, Conn.)2019
Prediction of incident hypertension and arterial stiffness using the non-insulin-based metabolic score for insulin resistance (METS-IR) index.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Metabolic score for insulin resistance and the incidence of cardiovascular disease: a meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- Association Between the Number of Metabolic Syndrome Components and Markers of Subclinical Vascular Damage: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Nonlinear association between metabolic score for insulin resistance (METS-IR) and prevalent hypertension: a cross-sectional study.BMC cardiovascular disorders · 2026Article
- Cardio-Cerebral Protective Effect of Moxibustion on Phlegm-Dampness Type Hypertension: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Combined with the insulin resistance index in assessing subclinical systolic function in newly diagnosed type 2 diabetes mellitus: an analysis based on automated functional imaging echocardiography.BMC endocrine disorders · 2025Article
- Insulin Resistance Indices Predict Mortality in Cardiovascular Disease: A Large-Scale NHANES Study With Machine Learning Validation.Food science & nutrition · 2025Article
- The association of the metabolic score for insulin resistance and metabolic dysfunction-related steatosis liver disease: a population-based observational study.European journal of medical research · 2025Observational
- Impact of cardiometabolic risk factors and its management on the reversion and progression of arterial stiffness.NPJ cardiovascular health · 2025Review
- Comparisons of various insulin resistance indices for new-onset metabolic syndrome before midlife: The CHIEF cohort study, 2014-2020.World journal of diabetes · 2025Article
- Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007-2018.Lipids in health and disease · 2025Article
- Association of metabolic score for insulin resistance with incident metabolic syndrome: a cohort study in middle-aged and older adult Chinese population.Frontiers in public health · 2025Article
- Associations of triglyceride-glucose index and metabolic score for insulin resistance with various hypertension phenotypes in children and adolescents: results from the 2017 China nutrition and health surveillance.Frontiers in endocrinology · 2025Article
- The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge.Frontiers in endocrinology · 2025Article
- Non-linear association between metabolic score for insulin resistance and diabetes mellitus in normal-weight middle-aged and older Chinese adults: a multicenter retrospective cohort study.Frontiers in nutrition · 2025Article
- Changes in the metabolic score for insulin resistance index for risk prediction of stroke in middle-aged and older Chinese population.The EPMA journal · 2024Article
- The Genetic Variants Influencing Hypertension Prevalence Based on the Risk of Insulin Resistance as Assessed Using the Metabolic Score for Insulin Resistance (METS-IR).International journal of molecular sciences · 2024Article
- Insulin resistance and sarcopenia: a prognostic longitudinal link to stroke risk in middle-aged and elderly Chinese population.BMC public health · 2024Article
- Non-insulin-based insulin resistance indices predict early neurological deterioration in elderly and middle-aged acute ischemic stroke patients in Northeast China.Scientific reports · 2024Article
- The association of dietary indices for hyperinsulinemia and insulin resistance with the risk of metabolic syndrome: a population-based cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Association between metabolic score for insulin resistance and clinical outcomes: insights from the Tehran lipid and glucose study.Nutrition & metabolism · 2024Article
Corrections and comments
- Commented on by
Authors and funding
24 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non-insulin-based IR indexes were developed as tools for metabolic screening. Here, we aimed to evaluate the novel non-insulin-based Metabolic Score for IR (METS-IR) index for the prediction of incident hypertension and arterial stiffness evaluated using pulse wave velocity (PWV) analysis, compared with other non-insulin-based IR indexes. We evaluated two populations, a cross-sectional evaluation of high-risk individuals (n = 305) with a wide range of metabolic comorbidities and dyslipidemia in whom PWV measurement was performed and a 3-year prospective cohort of normotensive individuals (N = 6850). We observed a positive correlation between METS-IR and PWV in the cross-sectional cohort, which was higher compared with other non-insulin-based fasting IR indexes; furthermore, PWV values >75th percentile were associated with the upper tercile of METS-IR values. In the prospective cohort, we observed an increased risk for incident hypertension for the upper METS-IR tercile (METS-IR ≥ 46.42; HR: 1.81, 95% CI: 1.41-2.34), adjusted for known cardiovascular risk factors, and observed that METS-IR had greater increases in the predictive capacity for hypertension along with SBP and the Framingham Hypertension Risk Prediction Model compared with other non-insulin-based IR indexes. Therefore, METS-IR is a novel non-insulin-based IR index which correlates with arterial stiffness and is a predictor of incident hypertension, complementary to previously validated risk prediction models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.