ArticleBritish journal of clinical pharmacology2019
Drug-induced aseptic meningitis: 329 cases from the French pharmacovigilance database analysis.
Article in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Post-COVID-19 Vaccination Meningitis and Meningoencephalitis: A Systematic Review of Case Series and Case Reports.The American journal of tropical medicine and hygiene · 2025Pooled it
- Acute Aseptic Meningitis Temporally Associated with Intravenous Polyclonal Immunoglobulin Therapy: A Systematic Review.Clinical reviews in allergy & immunology · 2024Pooled it
- Safety, tolerability, and immunogenicity of pentavalent meningococcal MenABCWY vaccine in healthy infants: A phase 2b randomized clinical trial.Human vaccines & immunotherapeutics · 2025Trial
- Long-term safety of cyclical rozanolixizumab in patients with generalized myasthenia gravis: Results from the Phase 3 MycarinG study and an open-label extension.Journal of neuromuscular diseases · 2025Trial
- Like father, like daughter: amoxicillin-induced aseptic meningitis in a female patient and her father: a case report.Journal of medical case reports · 2026Article
- A Case of Aseptic Meningitis Presenting With Widespread Non-Dermatomal Neuropathic Pain.Journal of general and family medicine · 2026Article
- A Rare Occurrence of Amoxicillin-Induced Aseptic Meningitis in a Young Adult: A Case Report.Cureus · 2025Article
- Recurrent amoxicillin-induced aseptic meningitis.BMJ case reports · 2025Article
- A Case of Rheumatoid Meningitis Diagnosed with FLAIR Images and Anti-cyclic Citrullinated Peptide Antibodies Levels.NMC case report journal · 2024Article
- Amoxicillin-induced aseptic meningitis: clinical features, diagnosis and management.European journal of medical research · 2023Article
- Clinical Characteristics, Diagnosis, and Management of Aseptic Meningitis Induced by Trimethoprim-Sulfamethoxazole.Infection and drug resistance · 2023Article
- Drug Safety in Episodic Migraine Management in Adults Part 1: Acute Treatments.Current pain and headache reports · 2022Review
- Intravenous Immunoglobulin-Induced Aseptic Meningitis-A Narrative Review of the Diagnostic Process, Pathogenesis, Preventative Measures and Treatment.Journal of clinical medicine · 2022Review
- Aseptic Meningitis in Oral Medicine: Exploring the Key Elements for a Challenging Diagnosis: A Review of the Literature and Two Case Reports.International journal of environmental research and public health · 2022Review
- Aseptic meningitis after BNT-162b2 COVID-19 vaccination.Brain, behavior, & immunity - health · 2022Article
- Aseptic Neutrophilic Meningitis With Hypoglycorrhachia Following a Single Ocrelizumab Infusion.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- A Case Report of Antibiotic-Induced Aseptic Meningitis in Psoriasis.Hawai'i journal of health & social welfare · 2021Article
- Intravenous immunoglobulin-induced aseptic meningitis in a patient with Miller Fisher syndrome.Acta neurologica Belgica · 2020Article
- Drug-Induced Aseptic Meningitis Following Spinal Anesthesia.European journal of case reports in internal medicine · 2020Article
- Drug-induced aseptic meningitis: 329 cases from the French pharmacovigilance database analysis.British journal of clinical pharmacology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDrug-induced aseptic meningitis (DIAM) is an adverse drug reaction of exclusion; only few studies have addressed this iatrogenic disease. The aim was to characterize DIAM and to identify suspected drugs.
methodsData were collected from the analysis of the French Pharmacovigilance Database from inception (1 January 1985) to 8 March 2017. All cases were initially analysed according to the French imputability method by institutional pharmacologists (clinicians or pharmacists). Further analyses of well documented cases were then performed.
resultsIn this study, 329 cases of aseptic meningitis were retrieved from the French Pharmacovigilance Database for a total of 429 suspected drugs. Analysis of 203 well documented cases, including 282 drugs, showed that the main reported classes were intravenous polyvalent immunoglobulin, nonsteroidal anti-inflammatory drugs (NSAIDs), vaccines, antimicrobials, intrathecal antimetabolites, corticosteroids and antalgics/anaesthetics (except NSAIDs). Lymphocytic (33.0%) and purulent (44.8%) meningitis represented the majority of cases of aseptic meningitis. In other cases, the cerebrospinal fluid was mixed (45-55% of neutrophils +45-55% of lymphocytes) or data about cerebrospinal fluid composition were lacking. Most DIAM cases (96%) had a favourable reported outcome with full recovery or minimal residual symptoms.
conclusionThe most frequently involved drugs in DIAM were intravenous polyvalent immunoglobulin, NSAIDs, vaccines, and antimicrobials and this without being able to differentiate them in terms of biological characteristics. Although further studies are needed to better understand the pathophysiological mechanisms of DIAM, a continuous enrichment of pharmacovigilance databases is essential to identify new signals and to help clinicians in the understanding of DIAM.
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