ArticleJournal of the American Chemical Society2019
Antitumor Activity of 1,18-Octadecanedioic Acid-Paclitaxel Complexed with Human Serum Albumin.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity.Drug delivery · 2026Article
- Molecular Mechanisms of Interaction of Human Serum Albumin with the CD36 Receptor: Insights from Molecular Dynamics Simulations.International journal of molecular sciences · 2026Article
- Syntheses, Biological and Preclinical Evaluations, and Nanoparticle Formulations of the ROS-Activatable Prodrugs of Doxazolidine for Drug-Resistant Cancer Therapy.Molecular pharmaceutics · 2026Article
- PSMA-targeted fluorescent probe for NIR-II imaging in prostate cancer intraoperative navigation and tumor margin mapping.Theranostics · 2026Article
- LiCl-driven direct synthesis of mono-protected esters from long-chain dicarboxylic fatty acids.RSC advances · 2025Article
- Association of Neutrophil Percentage-to-Albumin Ratio with All-Cause and Cardiovascular Mortality in Maintenance Hemodialysis Patients: A Retrospective Study.Journal of inflammation research · 2025Article
- Article
- Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo.Nature communications · 2023Article
- Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics.Acta pharmaceutica Sinica. B · 2023Review
- Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin release in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- In Vivo Evaluation of (-)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site.Molecules (Basel, Switzerland) · 2022Article
- Development of Novel Tetrapyrrole Structure Photosensitizers for Cancer Photodynamic Therapy.Bioengineering (Basel, Switzerland) · 2022Review
- Innovations in Disease State Responsive Soft Materials for Targeting Extracellular Stimuli Associated with Cancer, Cardiovascular Disease, Diabetes, and Beyond.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Nanoparticulation of Prodrug into Medicines for Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Article
- Functionalized Particles Designed for Targeted Delivery.Polymers · 2021Review
- Surfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity.International journal of nanomedicine · 2021Article
- Lipids: chemical tools for their synthesis, modification, and analysis.Chemical Society reviews · 2020Review
- Poly(peptide): Synthesis, Structure, and Function of Peptide-Polymer Amphiphiles and Protein-like Polymers.Accounts of chemical research · 2020Article
- Polymer nanoparticle-assisted chemotherapy of pancreatic cancer.Therapeutic advances in medical oncology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Cassandra E CallmannDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.
Clare L M LeGuyaderDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.
Spencer T BurtonDepartments of Chemistry, Materials Science & Engineering, Biomedical Engineering, Chemistry of Life Processes Institute, International Institute for Nanotechnology, Simpson Querrey Institute , Northwestern University , Evanston , Illinois 60208 , United States.
Matthew P ThompsonDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.
Robert HennisDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.
Christopher BarbackDepartment of Radiology , University of California San Diego , La Jolla , California 92093 , United States.
Niel M HenriksenSkaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States.ORCID 0000-0002-7916-0757
Warren C ChanDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.
Matt J JaremkoDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.
Jin YangSkaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States.
Arnold GarciaSkaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States.
Michael D BurkartDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.ORCID 0000-0002-4472-2254
Michael K GilsonSkaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States.ORCID 0000-0002-3375-1738
Jeremiah D MomperSkaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States.
Paul A BertinElevance Renewable Sciences, Inc. 2501 Davey Road , Woodridge , Illinois 60517 , United States.
Nathan C GianneschiDepartment of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.ORCID 0000-0001-9945-5475
University of California San Diego · USNorthwestern University · USElevance Renewable Sciences (United States) · US
Funding
Contemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1MRegulation of Receptor Tyrosine KinasesR01GM065490 · NIGMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI DONOGHUE, DANIEL J · 2002 to 2005
$1.0MNCI NIH HHS T32 CA009523NIGMS NIH HHS R01 GM065490
Abstract
We describe the design, synthesis, and antitumor activity of an 18 carbon α,ω-dicarboxylic acid monoconjugated via an ester linkage to paclitaxel (PTX). This 1,18-octadecanedioic acid-PTX (
Indexed as
AnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationDicarboxylic AcidsDose-Response Relationship, DrugHumansMiceMice, NudeModels, MolecularMolecular StructureNeoplasms, ExperimentalPaclitaxelProdrugsSerum Albumin, HumanStearic AcidsAntineoplastic AgentsDicarboxylic Acidsoctadecane-1,18-dioic acidPaclitaxelProdrugsSerum Albumin, HumanStearic Acids
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.