ArticleAutism research : official journal of the International Society for Autism Research2019
The language network in autism: Atypical functional connectivity with default mode and visual regions.
Article in Autism research : official journal of the International Society for Autism Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Heterogeneous functional state dynamics and its structural substrates in male individuals with autism spectrum disorder.Molecular psychiatry · 2026Article
- Age-stratified individual-specific subspace of autism spectrum disorder based on common orthogonal basis extraction algorithm improves the accuracy of clinical symptoms prediction.BMC psychiatry · 2026Article
- Contribution of attentional mechanisms to verbal and nonverbal communication in boys with ASD.European child & adolescent psychiatry · 2026Article
- Atypical Resting-State and Task-Evoked EEG Signatures in Children with Developmental Language Disorder.Bioengineering (Basel, Switzerland) · 2026Article
- Brain function in language and associated networks in non- or minimally verbal children.Brain communications · 2026Article
- Neuroanatomical basis of language ability in an autism subgroup with moderate language deficits.European child & adolescent psychiatry · 2025Article
- The cerebellar glucose metabolism in moyamoya vasculopathy and its correlation with neurocognitive performance after cerebral revascularization surgery: a [European journal of nuclear medicine and molecular imaging · 2025Article
- Language networks in Autism Spectrum Disorder: A systematic review of connectivity-based fMRI studies.Review journal of autism and developmental disorders · 2025Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Youth Screen Media Activity Patterns and Associations With Behavioral Developmental Measures and Resting-state Brain Functional Connectivity.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD.Molecular autism · 2023Article
- Neural Correlates of Audiovisual Speech Processing in Autistic and Non-Autistic Youth.Multisensory research · 2023Article
- Occupation-modulated language networks and its lateralization: A resting-state fMRI study of seafarers.Frontiers in human neuroscience · 2023Article
- Absence of associations with prefrontal cortex and cerebellum may link to early language and social deficits in preschool children with ASD.Frontiers in psychiatry · 2023Article
- fMRI BOLD and MEG theta power reflect complementary aspects of activity during lexicosemantic decision in adolescents with ASD.Neuroimage. Reports · 2022Article
- The atypical functional connectivity of Broca's area at multiple frequency bands in autism spectrum disorder.Brain imaging and behavior · 2022Article
- Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children.International journal of environmental research and public health · 2022Article
- Brain and Language Associations in Autism Spectrum Disorder: A Scoping Review.Journal of autism and developmental disorders · 2022Article
- Attenuated effective connectivity of large-scale brain networks in children with autism spectrum disorders.Frontiers in neuroscience · 2022Article
- The Altered Pattern of the Functional Connectome Related to Pathological Biomarkers in Individuals for Autism Spectrum Disorder Identification.Frontiers in neuroscience · 2022Article
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8 authors.
Funding
Abstract
Autism spectrum disorders (ASDs) are neurodevelopmental disorders associated with atypical brain connectivity. Although language abilities vary widely, they are impaired or atypical in most children with ASDs. Underlying brain mechanisms, however, are not fully understood. The present study examined intrinsic functional connectivity (iFC) of the extended language network in a cohort of 52 children and adolescents with ASDs (ages 8-18 years), using resting-state functional magnetic resonance imaging. We found that, in comparison to typically developing peers (n = 50), children with ASDs showed increased connectivity between some language regions. In addition, seed-to-whole brain analyses revealed increased connectivity of language regions with posterior cingulate cortex (PCC) and visual regions in the ASD group. Post hoc effective connectivity analyses revealed a mediation effect of PCC on the iFC between bilateral inferior frontal and visual regions in an ASD subgroup. This finding qualifies and expands on previous reports of recruitment of visual areas in language processing in ASDs. In addition, increased iFC between PCC and visual regions was linked to lower language scores in this ASD subgroup, suggesting that increased connectivity with visual cortices, mediated by default mode regions, may be detrimental to language abilities. Autism Res 2019, 12: 1344-1355. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined the functional connectivity between regions of the language network in children with autism spectrum disorders (ASDs) compared to typically developing peers. We found connectivity to be intact between core language in the ASD group, but also showed abnormally increased connectivity between regions of an extended language network. Additionally, connectivity was increased with regions associated with brain networks responsible for self-reflection and visual processing.
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