Evidence map›Paper›PMID 31317580›Full record

ArticleJournal of veterinary internal medicine2019

The use of focused cardiac ultrasound to screen for occult heart disease in asymptomatic cats.

Kerry A Loughran, John E Rush, Elizabeth A Rozanski, Mark A Oyama, Éva Larouche-Lebel, Marc S Kraus

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Feline friendly POCUS: how to implement it into your daily practice.Journal of feline medicine and surgery · 2024
    Review
  5. Left atrial measurement in lateralThe Canadian veterinary journal = La revue veterinaire canadienne · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Validation of a commercial human ELISA to measure hyaluronic acid concentration in feline plasma.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
  11. The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy.Journal of feline medicine and surgery · 2021
    Article
  12. Article
  13. Review
  14. Occurrences of heart disease in apparently healthy cats in Klang Valley, Malaysia.Journal of advanced veterinary and animal research · 2020
    Article
  15. Article
  16. Joint virtual issue on recent advances in veterinary cardiac imaging.Journal of veterinary internal medicine · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kerry A LoughranDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.
John E RushDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.ORCID https://orcid.org/0000-0002-8277-8996
Elizabeth A RozanskiDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.ORCID https://orcid.org/0000-0003-3233-8930
Mark A OyamaDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-5218-9226
Éva Larouche-LebelDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Marc S KrausDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-8715-5376
Tufts University · USUniversity of Pennsylvania · US

Funding

Barkley FundMorris Animal Foundation D14FE-502
6 · The paper itself

Abstract

backgroundFocused cardiac ultrasound (FCU) helps detect occult heart disease in human patients. HYPOTHESIS: Focused cardiac ultrasound by a nonspecialist practitioner (NSP) will increase the detection of occult heart disease in asymptomatic cats compared with physical examination and ECG. ANIMALS: Three hundred forty-three client-owned cats: 54 excluded and 289 analyzed.

methodsMulticenter prospective cohort study. Twenty-two NSPs were trained to perform FCU. Cats without clinical signs of heart disease were recruited, and NSPs performed the following in sequential order: physical examination, ECG, FCU, and point-of-care N-terminal pro-B-type natriuretic peptide assay (POC-BNP). After each step, NSPs indicated yes, no, or equivocal as to whether they believed heart disease was present. The level of agreement between the NSP diagnosis and a blinded cardiologist's diagnosis after echocardiogram was evaluated using Cohen's kappa test.

resultsCardiologist diagnoses included 148 normal cats, 102 with heart disease, and 39 equivocal ones. Agreement between NSP and cardiologist was slight after physical examination (kappa 0.253 [95% CI, 0.172-0.340]), did not increase after ECG (0.256 [0.161-0.345]; P = .96), increased after FCU (0.468 [0.376-0.558]; P = .002), and the level of agreement was similar after POC-BNP (0.498 [0.419-0.580]; P = .67). In cats with mild, moderate, and marked occult heart disease, the proportion of cats having a NSP diagnosis of heart disease after FCU was 45.6%, 93.1%, and 100%, respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: Focused cardiac ultrasound performed by NSPs increased the detection of occult heart disease, especially in cats with moderate to marked disease. Focused cardiac ultrasound appears to be a feasible and useful tool to assist NSPs in the detection of heart disease in cats.

Indexed as

AnimalsCat DiseasesCatsCohort StudiesEchocardiographyElectrocardiographyFemaleHeart DiseasesMaleNatriuretic Peptide, BrainProspective StudiesUltrasonographyNatriuretic Peptide, BraincardiomyopathyECGechocardiographyfelinemyocardial disease

Identifiers

PMID31317580
PMCPMC6766524
OpenAlexW2963476410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.