ArticleEndocrine2019
Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis.
Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Pooled it
- Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Pooled it
- What are the real rates of temporary hypoparathyroidism following thyroidectomy? It is a matter of definition: a systematic review.Endocrine · 2021Pooled it
- Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial.The British journal of surgery · 2023Trial
- Italian guidelines for the management of adult individuals with post-surgical hypoparathyroidism.Journal of endocrinological investigation · 2026Article
- Article
- Predicting permanent hypoparathyroidism after thyroidectomy: role of early postoperative parathyroid hormone levels and surgical factors.BMC endocrine disorders · 2026Article
- Clinical manifestations of injured tracheal and esophageal branches of the recurrent laryngeal nerve following thyroid surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- In Vivo Engraftment and Functional Efficacy of a 3D-Bioprinted Human Parathyroid Equivalent.Medicina (Kaunas, Lithuania) · 2026Article
- Learning curve in autofluorescence-guided thyroid surgery.Frontiers in endocrinology · 2026Article
- Hypoparathyroidism: a brief historical overview for clinicians.Frontiers in endocrinology · 2026Review
- Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- Oncological characteristics predict permanent hypoparathyroidism following total thyroidectomy for papillary thyroid carcinoma: a study from China.Gland surgery · 2025Article
- Progress and future prospects for the surgical treatment of permanent hypoparathyroidism after thyroid surgery: a narrative review.BMC surgery · 2025Review
- Article
- The BMI impact on thyroidectomy-related morbidity; a case-matched single institutional analysis.BMC surgery · 2025Observational
- Clinical significance and risk factors of incidental parathyroidectomy after total thyroidectomy.Endocrine · 2025Article
- The Impact of Sunlight Exposure on Postoperative Hypoparathyroidism: A Retrospective Analysis from Two Greek Centers.Journal of clinical medicine · 2025Article
- Impaired renal function in patients with permanent hypoparathyroidism after thyroidectomy: analysis of a nationwide cohort in Spain.Endocrine · 2025Article
- Hypoparathyroidism: Similarities and differences between Western and Eastern countries.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 19 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe prevalence of postoperative hypoparathyroidism has been studied in registries and in surgical series with highly variable and imprecise results. However, the frequency of this hormonal deficiency in the clinical practice of endocrinologists is not known with accuracy. We aimed to assess the prevalence and risk factors of hypoparathyroidism in patients undergoing total thyroidectomy in Spain.
methodsWe designed a retrospective, multicentre and nation-wide protocol including all patients with total thyroidectomy who were seen in the endocrinology clinic of the participant centers from January to March 2018. Prevalence of hypoparathyroidism was evaluated at discharge of surgery, 3-6 months after surgery, 12 months after surgery and at last visit. Twenty hospitals participated in the study.
resultsOf 1792 patients undergoing total thyroidectomy, 866 (48.3%) developed postoperative hypoparathyroidism at discharge of surgery. Most of them recover parathyroid function over time. Prevalence of hypoparathyroidism at 3-6 months, 12 months and at last visit was 22.9%, 16.7% and 14.5%, respectively. The risk of developing definitive hypoparathyroidism was related to the presence of parathyroid tissue at histology, lymph node dissection, and two-stage thyroidectomy. Patients with thyroid cancer, with higher postoperative calcium levels and treated by expert surgical teams exhibited lower risk of developing permanent hypoparathyroidism.
conclusionsAlthough most patients with postsurgical hypoparathyroidism recover parathyroid function, the prevalence of permanent disease in clinical practice is non negligible (14.5%). Postoperative calcium, extent and timing of surgery, the presence of cancer, expert surgical team, and parathyroid tissue at histology are predictors of permanent hypoparathyroidism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.