Evidence map›Paper›PMID 31317370›Full record

ArticleClinical journal of gastroenterology2020

Vanishing bile duct syndrome arising in a patient with HIV infection sequentially treated with trimethoprim/sulfamethoxazole and dapsone.

Pradeep Reddy Kathi, Maher Tama, Murray Ehrinpreis, Milton Mutchnick, Maria Westerhoff, Jonathan Mowers, Robert John Fontana

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pradeep Reddy KathiDepartment of Internal Medicine, Wayne State University, Detroit, MI, USA. pradeepreddyk.14@gmail.com.ORCID http://orcid.org/0000-0002-0556-6543
Maher TamaDivision of Gastroenterology and Hepatology, Wayne State University, Detroit, MI, USA.
Murray EhrinpreisDivision of Gastroenterology and Hepatology, Wayne State University, Detroit, MI, USA.
Milton MutchnickDivision of Gastroenterology and Hepatology, Wayne State University, Detroit, MI, USA.
Maria WesterhoffDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Jonathan MowersDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Robert John FontanaDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Wayne State University · USUniversity of Michigan · US

Funding

Michigan Hepatotoxicity Clinical Research Network Renewal 2018U01DK065184 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERT J FONTANA · 2003 to 2026
$7.0M
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2U01-DK065184-06
6 · The paper itself

Abstract

Trimethoprim/sulfamethoxazole is well known to cause intra-hepatic cholestasis which in rare instances can be prolonged and lead to vanishing bile duct syndrome. The risk regarding the potential for cross-reactivity between structurally related molecules such as dapsone and trimethoprim/sulfamethoxazole in causing hepatotoxicity is scarce. Herein, we report a case of vanishing bile duct syndrome following dapsone use in a patient with HIV infection and a recent history of trimethoprim/sulfamethoxazole-induced cholestasis. The patient had severe and protracted cholestasis during 2 years of follow-up and eventually died of liver failure.

Indexed as

Anti-Infective AgentsCholestasis, IntrahepaticDapsoneDrug InteractionsDrug Therapy, CombinationFatal OutcomeHIV InfectionsHumansMaleMiddle AgedSyndromeTrimethoprim, Sulfamethoxazole Drug CombinationAnti-Infective AgentsDapsoneTrimethoprim, Sulfamethoxazole Drug CombinationDapsoneDrug-induced liver injuryHIVTrimethoprim sulfamethoxazoleVanishing bile duct syndrome

Identifiers

PMID31317370
OpenAlexW2961778227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.