Evidence map›Paper›PMID 31317191›Full record

ReviewSchizophrenia bulletin2019

The Hyperfocusing Hypothesis: A New Account of Cognitive Dysfunction in Schizophrenia.

Steven J Luck, Britta Hahn, Carly J Leonard, James M Gold

Abstract readReview
In one paragraph

Review in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Trial
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  6. Review
  7. Review
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  12. Anosognosia in schizophrenia.CNS spectrums · 2024
    Review
  13. Ten years ofSchizophrenia research. Cognition · 2024
    Article
  14. Article
  15. Article
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Steven J LuckCenter for Mind and Brain, University of California, Davis, CA.
Britta HahnMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD.
Carly J LeonardDepartment of Psychology, University of Colorado Denver, Denver, CO.
James M GoldMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD.

Funding

Cognitive Neuroscience of Attention in SchizophreniaR01MH065034 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI James M. Gold, STEVEN J LUCK · 2001 to 2026
$13.9M
NIMH NIH HHS R01 MH065034
6 · The paper itself

Abstract

Impairments in basic cognitive processes such as attention and working memory are commonly observed in people with schizophrenia and are predictive of long-term outcome. In this review, we describe a new theory-the hyperfocusing hypothesis-which provides a unified account of many aspects of impaired cognition in schizophrenia. This hypothesis proposes that schizophrenia involves an abnormally narrow but intense focusing of processing resources. This hyperfocusing impairs the ability of people with schizophrenia to distribute attention among multiple locations, decreases the number of representations that can simultaneously be maintained in working memory, and causes attention to be abnormally captured by irrelevant inputs that share features with active representations. Evidence supporting the hyperfocusing hypothesis comes from a variety of laboratory tasks and from both behavioral and electrophysiological measures of processing. In many of these tasks, people with schizophrenia exhibit supranormal effects of task manipulations, which cannot be explained by a generalized cognitive deficit or by nonspecific factors such as reduced motivation or poor task comprehension. In addition, the degree of hyperfocusing in these tasks is often correlated with the degree of impairment in measures of broad cognitive function, which are known to be related to long-term outcome. Thus, the mechanisms underlying hyperfocusing may be a good target for new treatments targeting cognitive deficits in schizophrenia.

Indexed as

AttentionSchizophrenic PsychologyBrainCognitive DysfunctionElectroencephalographyFunctional NeuroimagingHumansMagnetic Resonance ImagingMemory, Short-TermPsychological TheorySchizophreniaattentionattentional captureERPsfMRIuseful field of viewworking memory

Identifiers

PMID31317191
PMCPMC6737469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.