ArticleAnnals of translational medicine2019
Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- 3D-printed porous Ti6Al4V scaffolds for long bone repair in animal models: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Advances in Titanium-Based Biomaterial for Human Bone Scaffolds: Narrative Review on Design, Fabrication, Surface Engineering, Implantation, and Biological Evaluation.Materials (Basel, Switzerland) · 2025Review
- Polydopamine-based Surface Modifications for Tissue Engineering and Biosensing: From Understanding Chemistry to Diverse Applications.JOM (Warrendale, Pa. : 1989) · 2025Article
- Dual-functional titanium implants via polydopamine-mediated lithium and copper co-incorporation: synergistic enhancement of osseointegration and antibacterial efficacy.Frontiers in bioengineering and biotechnology · 2025Article
- Shape Memory Polymer Scaffolds-Utility for In Vitro Osteogenesis of Canine Multipotent Stromal Cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Sustained BMP-2 delivery via alginate microbeads and polydopamine-coated 3D-Printed PCL/β-TCP scaffold enhances bone regeneration in long bone segmental defects.Journal of orthopaedic translation · 2024Article
- 3D-Printed Demineralized Bone Matrix-Based Conductive Scaffolds Combined with Electrical Stimulation for Bone Tissue Engineering Applications.ACS applied bio materials · 2024Article
- Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives.Drug design, development and therapy · 2024Review
- Small-molecule amines: a big role in the regulation of bone homeostasis.Bone research · 2023Review
- Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential.Materials (Basel, Switzerland) · 2022Article
- Evaluation of cell adhesion and osteoconductivity in bone substitutes modified by polydopamine.Frontiers in bioengineering and biotechnology · 2022Review
- Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation.Frontiers in bioengineering and biotechnology · 2022Review
- Definition, measurement, and function of pore structure dimensions of bioengineered porous bone tissue materials based on additive manufacturing: A review.Frontiers in bioengineering and biotechnology · 2022Review
- Biomaterials for bone regeneration: an orthopedic and dentistry overview.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Review
- Polynorepinephrine: state-of-the-art and perspective applications in biosensing and molecular recognition.Analytical and bioanalytical chemistry · 2020Article
- Collagen Scaffolds Containing Hydroxyapatite-CaO Fiber Fragments for Bone Tissue Engineering.Polymers · 2020Article
- Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation.Theranostics · 2020Article
- The combination of multi-functional ingredients-loaded hydrogels and three-dimensional printed porous titanium alloys for infective bone defect treatment.Journal of tissue engineeringArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTitanium implants are widely used in orthopedic and dental for more than 30 years. Its stable physicochemical properties and mechanical strength are indeed appropriate for implantation. However, the Bioinertia oxidized layer and higher elastic modulus often lead to the early implantation failure.
methodsIn this study, we proposed a simple design of porous structure to minimize the disparity between scaffold and natural bone tissue, and introduced a one-step reaction to form a polydopamine (PDA) layer on the surface of titanium for the purpose of improving osteogenesis as well. The porous scaffolds with pore size of 400 µm and porosity of 44.66% were made by additive manufacturing. The cell behavior was tested by seeding MC3T3-E1 cells on Ti6Al4V films for 15 days. The biomechanical properties were then analyzed by finite element (FE) method and the
resultsAccording to the achieved results, it was revealed that the immersion for 40 min with dopamine could significantly improve the cell adhesion. The proposed method for design of porous structure can avoid the stress shielding effect and bone growth inside the PDA coating scaffolds, which were observed at the early stage of bone healing process.
conclusionsIt can be concluded that the proposed PDA coating method is effective in promoting early osteogenesis, as well as being easy to operate, and can be helpful in the future clinical application of titanium implants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.