ArticleFrontiers in veterinary science2019
The Role of Tryptophan-Kynurenine in Feather Pecking in Domestic Chicken Lines.
Article in Frontiers in veterinary science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Chicken IDO2 and TDO2: Biochemical Characteristics and Regulatory Roles in Avian Tryptophan Metabolism and Inflammatory Response.Animals : an open access journal from MDPI · 2026Article
- Preference and behavioral responses to synbiotic supplementation via drinking water in laying hens under social stress.Poultry science · 2026Article
- Optimizing tryptophan supplementation for stress reduction and enhanced productivity in aging laying hens.Journal of animal science and technology · 2026Article
- Innovations in Quail Welfare: Integrating Environmental Enrichment, Nutrition and Genetic Advances for Improved Health and Productivity.Veterinary medicine and science · 2025Review
- The Glutamatergic System Regulates Feather Pecking Behaviors in Laying Hens Through the Gut-Brain Axis.Animals : an open access journal from MDPI · 2025Article
- DietaryFrontiers in microbiology · 2025Article
- The therapeutic effects ofGut microbiome (Cambridge, England) · 2025Review
- Malfunctioned inflammatory response and serotonin metabolism at the microbiota-gut-brain axis drive feather pecking behavior in laying hens.Poultry science · 2023Article
- Brain-Derived Neurotrophic Factor, Kynurenine Pathway, and Lipid-Profiling Alterations as Potential Animal Welfare Indicators in Dairy Cattle.Animals : an open access journal from MDPI · 2023Article
- An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway.International journal of molecular sciences · 2022Review
- Embryonic transcriptome unravels mechanisms and pathways underlying embryonic development with respect to muscle growth, egg production, and plumage formation in native and broiler chickens.Frontiers in genetics · 2022Article
- Regulatory T Cell Modulation byFrontiers in veterinary science · 2022Article
- Synergy of Dietary Quercetin and Vitamin E Improves Cecal Microbiota and Its Metabolite Profile in Aged Breeder Hens.Frontiers in microbiology · 2022Article
- L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets.Scientific reports · 2021Article
- Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens.Scientific reports · 2021Article
- Immunomodulatory, behavioral, and nutritional response of tryptophan application on poultry.Veterinary world · 2021Review
- Production of viable chicken by allogeneic transplantation of primordial germ cells induced from somatic cells.Nature communications · 2021Article
- The Prevalence of Integument Injuries and Associated Risk Factors Among Canadian Turkeys.Frontiers in veterinary science · 2021Article
- Cecal motility and the impact of Lactobacillus in feather pecking laying hens.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research into the role of tryptophan (TRP) breakdown away from the serotonergic to the kynurenine (KYN) pathway by stimulating the brain-endocrine-immune axis system interaction has brought new insight into potential etiologies of certain human behavioral and mental disorders. TRP is involved in inappropriate social interactions, such as feather-destructive pecking behavior (FP) in birds selected for egg laying. Therefore, our goal was to determine the effect of social disruption stress on FP and the metabolism of the amino acids TRP, phenylalanine (PHE), tyrosine (TYR), their relevant ratios, and on large neutral amino acids which are competitors with regard to their transport across the blood-brain barriers, at least in the human system, in adolescent birds selected for and against FP behavior. We used 160 laying hens selected for high (HFP) or low (LFP) FP activity and an unselected control line (UC). Ten pens with 16 individuals each (4 HFP birds; 3 LFP birds; 9 UC birds) were used. At 16 weeks of age, we disrupted the groups twice in 5 pens by mixing individuals with unfamiliar birds to induce social stress. Blood plasma was collected before and after social disruption treatments, to measure amino acid concentrations. Birds FP behavior was recorded before and after social disruption treatments. HFP birds performed significantly more FP and had lower KYN/TRP ratios. We detected significantly higher FP activity and significantly lower plasma PHE/TYR ratios and a trend to lower KYN/TRP ratios in socially disrupted compared to control pens. This might indicate that activating insults for TRP catabolism along the KYN axis in laying hens differs compared to humans and points toward the need for a more detailed analysis of regulatory mechanisms to understand the role of TRP metabolism for laying hen immune system and brain function.
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Registered trials
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