Evidence map›Paper›PMID 31316980›Full record

ArticleFrontiers in cell and developmental biology2019

Urinary Cell Adhesion Molecule 1 Is a Novel Biomarker That Links Tubulointerstitial Damage to Glomerular Filtration Rates in Chronic Kidney Disease.

Man Hagiyama, Yoshihisa Nakatani, Yasutoshi Takashima, Takashi Kato, Takao Inoue, Ryuichiro Kimura, Tomoyuki Otani, Yasufumi Sato, Hideo Mori, Shuji Arima and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Predicting the germline dependence of hematuria risk in prostate cancer radiotherapy patients.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. The Role of Cell Adhesion Molecule 1 (CADM1) in Cutaneous Malignancies.International journal of molecular sciences · 2020
    Review
  10. Decreased Urinary Levels ofInternational journal of molecular sciences · 2020
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Man HagiyamaDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Yoshihisa NakataniDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Yasutoshi TakashimaDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Takashi KatoDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Takao InoueDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Ryuichiro KimuraDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Tomoyuki OtaniDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Yasufumi SatoDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Hideo MoriDepartment of Pathology, Osaka Rosai Hospital, Sakai, Japan.
Shuji ArimaDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Akihiko ItoDepartment of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Kindai University · JPOsaka Rosai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member strongly expressed on renal tubular epithelia in the urinary tract. Enzymatic cleavage of its ectodomain increases in chronic kidney disease (CKD), and is assumed to contribute to tubulointerstitial lesion formation. Because the cleaved ectodomain fragments are likely to be released into the urine, a sandwich enzyme-linked immunosorbent assay (ELISA) system for urinary CADM1 was developed using two anti-ectodomain antibodies. Urinary CADM1 concentrations in patients with CKD based on various forms of glomerulonephritis and nephropathy (

Indexed as

cell adhesion molecule 1chronic kidney diseaseectodomain sheddingELISAtubulointerstitial lesion

Identifiers

PMID31316980
PMCPMC6610501
OpenAlexW2948586380

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.