ReviewFrontiers in pediatrics2019
Aetiological Significance of Infectious Stimuli in Kawasaki Disease.
Review in Frontiers in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Kawasaki disease recurrence in the COVID-19 era: a systematic review of the literature.Italian journal of pediatrics · 2021Pooled it
- Coronary artery lesions in pediatric scrub typhus: A case series from Guangzhou, China.PLoS neglected tropical diseases · 2026Article
- Protective role of complement signaling in Kawasaki disease vasculitis.JCI insight · 2026Article
- Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation.Current issues in molecular biology · 2026Article
- Infectious mononucleosis complicated with Kawasaki disease: Two case reports and literature review.Pediatric investigation · 2025Article
- Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases.Disease models & mechanisms · 2025Article
- Value of cystatin C for Kawasaki disease with coronary artery aneurysm.Translational pediatrics · 2025Article
- Associations of infection burden with Kawasaki disease in a population-based setting during 30 years.RMD open · 2025Article
- Identification of key ferroptosis‑related biomarkers in Kawasaki disease by clinical and experimental validation.Biomedical reports · 2025Article
- Article
- Secular trend of Kawasaki disease and its correlation with viral activity in Taiwan: a nationwide population-based study.BMC public health · 2024Article
- Concomitant Kawasaki Disease and Rotavirus Infection-More Than Just a Coincidence: A Case Report.Tropical medicine and infectious disease · 2023Article
- Intravenous Immunoglobulin in Kawasaki Disease-Evolution and Pathogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2023Review
- Exploring the diagnostic value of eosinophil-to-lymphocyte ratio to differentiate Kawasaki disease from other febrile diseases based on clinical prediction model.Scientific reports · 2023Article
- Research trends on causes of Kawasaki disease in the COVID-19 era: focus on viral infections.Clinical and experimental pediatrics · 2023Article
- Review
- Gut Microbiota Dysbiosis in Childhood Vasculitis: A Perspective Comparative Pilot Study.Journal of personalized medicine · 2022Article
- Dermatological manifestations of the Coronavirus disease 2019 in children: a systemic review.Postepy dermatologii i alergologii · 2022Review
- An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease.Nature communications · 2022Article
- Temporal Correlation Between Kawasaki Disease and Infectious Diseases in South Korea.JAMA network open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is a pediatric vasculitis syndrome that is often involves coronary artery lesions (e. g., coronary artery aneurysms). Although its causal factors and entire pathogenesis remain elusive, the available evidence indicates that the pathogenesis of KD is closely associated with dysregulation of immune responses to various viruses or microbes. In this short review, we address several essential aspects of the etiology of KD with respect to the immune response to infectious stimuli: 1) the role of viral infections, 2) the role of bacterial infections and the superantigen hypothesis, 3) involvement of innate immune response including pathogens/microbe-associated molecular patterns and complement pathways, and 4) the influence of genetic background on the response to infectious stimuli. Based on the clinical and experimental evidence, we discuss the possibility that a wide range of microbes and viruses could cause KD through common and distinct immune processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.