Evidence map›Paper›PMID 31316919›Full record

ArticleFrontiers in cellular and infection microbiology2019

Miltefosine-Lopinavir Combination Therapy Against

Karina M Rebello, Valter V Andrade-Neto, Claudia Regina B Gomes, Marcos Vinícius N de Souza, Marta H Branquinha, André L S Santos, Eduardo Caio Torres-Santos, Claudia M d'Avila-Levy

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. In Vitro Assessment of the Combined Activity of Amphotericin B and CuTropical medicine and infectious disease · 2025
    Article
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  5. Current leishmaniasis drug discovery.RSC medicinal chemistry · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. A clioquinol-containing PluronicParasite (Paris, France) · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Karina M RebelloLaboratório de Estudos Integrados em Protozoologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Valter V Andrade-NetoLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Claudia Regina B GomesLaboratório de Síntese de Substâncias no Combate a Doenças Tropicais, Farmanguinhos, FIOCRUZ, Rio de Janeiro, Brazil.
Marcos Vinícius N de SouzaLaboratório de Síntese de Substâncias no Combate a Doenças Tropicais, Farmanguinhos, FIOCRUZ, Rio de Janeiro, Brazil.
Marta H BranquinhaLaboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Instituto de Microbiologia Paulo de Góes, UFRJ, Rio de Janeiro, Brazil.
André L S SantosLaboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Instituto de Microbiologia Paulo de Góes, UFRJ, Rio de Janeiro, Brazil.
Eduardo Caio Torres-SantosLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Claudia M d'Avila-LevyLaboratório de Estudos Integrados em Protozoologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Concurrently, leishmaniasis and AIDS are global public health issues and the overlap between these diseases adds additional treats to the management of co-infected patients. Lopinavir (LPV) has a well characterized anti-HIV and leishmanicidal action, and to analyze its combined action with miltefosine (MFS) could help to envisage strategies to the management of co-infected patients. Here, we evaluate the interaction between LPV and MFS against

Indexed as

Administration, OralAnimalsAntiprotozoal AgentsCoinfectionDisease Models, AnimalDrug CombinationsDrug SynergismFemaleHIV InfectionsInhibitory Concentration 50Leishmania infantumLeishmaniasis, VisceralLiverLopinavirMacrophages, PeritonealMiceAntiprotozoal AgentsDrug CombinationsLopinavirmiltefosinePhosphorylcholinechemotherapyco-infectionHIVHIV-PIleishmaniasistreatment

Identifiers

PMID31316919
PMCPMC6611157
OpenAlexW2955270342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.