ArticleIUCrJ2019
Radiation damage in small-molecule crystallography: fact not fiction.
Article in IUCrJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Are crystal structures getting better? A temporal and elemental analysis of the Cambridge Structural Database.Acta crystallographica. Section C, Structural chemistry · 2026Article
- Multi-Crystal X-Ray Diffraction (MCXRD) Bridges the Crystallographic Characterisation Gap in Chemistry and Materials Science: Application to MOFs.Angewandte Chemie (International ed. in English) · 2026Article
- The Impact of X-ray Damage in Chemical Crystalline Materials and New Opportunities for Small Molecule Serial Crystallography.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Powder diffraction data beyond the pattern: a practical review.Journal of applied crystallography · 2025Review
- Comprehensive microcrystal electron diffraction sample preparation for cryo-EM.Nature protocols · 2025Review
- Doses for X-ray and electron diffraction: New features in RADDOSE-3D including intensity decay models.Protein science : a publication of the Protein Society · 2024Article
- Radiation damage as a source of information.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2024Article
- Lattice response to the radiation damage of molecular crystals: radiation-induced versus thermal expansivity.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2024Article
- Incommensurate structures and radiation damage in RbActa crystallographica Section B, Structural science, crystal engineering and materials · 2023Article
- MicroED in drug discovery.Current opinion in structural biology · 2023Review
- A mixed phosphine sulfide/selenide structure as an instructional example for how to evaluate the quality of a model.Acta crystallographica. Section E, Crystallographic communications · 2023Article
- Variability in X-ray induced effects in [Rh(COD)Cl]Physical chemistry chemical physics : PCCP · 2022Article
- LED-pump-X-ray-multiprobe crystallography for sub-second timescales.Communications chemistry · 2022Article
- The benefits of CuIUCrJ · 2022Article
- Formation of Co-O bonds and reversal of thermal annealing effects induced by X-ray irradiation in (Y, Co)-codoped CeOScientific reports · 2022Article
- Article
- 3D Electron Diffraction for Chemical Analysis: Instrumentation Developments and Innovative Applications.Chemical reviews · 2021Review
- Establishing electron diffraction in chemical crystallography.Nature reviews. Chemistry · 2021Review
- Article
- Negative X-ray expansion in cadmium cyanide.Materials horizons · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally small-molecule crystallographers have not usually observed or recognized significant radiation damage to their samples during diffraction experiments. However, the increased flux densities provided by third-generation synchrotrons have resulted in increasing numbers of observations of this phenomenon. The diversity of types of small-molecule systems means it is not yet possible to propose a general mechanism for their radiation-induced sample decay, however characterization of the effects will permit attempts to understand and mitigate it. Here, systematic experiments are reported on the effects that sample temperature and beam attenuation have on radiation damage progression, allowing qualitative and quantitative assessment of their impact on crystals of a small-molecule test sample. To allow inter-comparison of different measurements, radiation-damage metrics (diffraction-intensity decline, resolution fall-off, scaling
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.