Evidence map›Paper›PMID 31316809›Full record

ArticleIUCrJ2019

Conservation of the structure and function of bacterial tryptophan synthases.

Karolina Michalska, Jennifer Gale, Grazyna Joachimiak, Changsoo Chang, Catherine Hatzos-Skintges, Boguslaw Nocek, Stephen E Johnston, Lance Bigelow, Besnik Bajrami, Robert P Jedrzejczak and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Meta-QTL analysis in wheat: progress, challenges and opportunities.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.Protein science : a publication of the Protein Society · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Karolina MichalskaCenter for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, IL 60367, USA.
Jennifer GaleBroad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
Grazyna JoachimiakMidwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA.
Changsoo ChangCenter for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, IL 60367, USA.ORCID https://orcid.org/0000-0003-1860-2969
Catherine Hatzos-SkintgesCenter for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, IL 60367, USA.
Boguslaw NocekCenter for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, IL 60367, USA.
Stephen E JohnstonBroad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
Lance BigelowMidwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA.
Besnik BajramiBroad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
Robert P JedrzejczakCenter for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, IL 60367, USA.
Samantha WellingtonBroad Institute of MIT and Harvard, Cambridge, MA 02141, USA.ORCID https://orcid.org/0000-0001-5072-2608
Deborah T HungBroad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
Partha P NagBroad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
Stewart L FisherBroad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
Michael EndresMidwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA.
Andrzej JoachimiakCenter for Structural Genomics of Infectious Diseases, University of Chicago, Chicago, IL 60367, USA.
Argonne National Laboratory · USBroad Institute · USUniversity of Chicago · US

Funding

The Midwest Center for Structural Genomics - Community ResourceR24GM115586 · NIGMS · UNIVERSITY OF CHICAGO · PI JOACHIMIAK, ANDRZEJ · 2015 to 2017
$2.8M
NIAID NIH HHS HHSN272201200026CNIAID NIH HHS HHSN272201700060CNIGMS NIH HHS R24 GM115586
6 · The paper itself

Abstract

Tryptophan biosynthesis is one of the most characterized processes in bacteria, in which the enzymes from

Indexed as

allosteric regulationcatalysiscrystal structuredrug discoveryenzyme inhibitorsenzyme mechanismsFrancisella tularensisLegionella pneumophilamolecular recognitionprotein structureStreptococcus pneumoniaestructure determinationtryptophantryptophan synthaseX-ray crystallography

Identifiers

PMID31316809
PMCPMC6608616
OpenAlexW2947822612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.