ArticleIUCrJ2019
Plasticity in zwitterionic drugs: the bending properties of Pregabalin and Gabapentin and their hydrates.
Article in IUCrJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Crystal property engineering using molecular-supramolecular equivalence: mechanical property alteration in hydrogen bonded systems.Chemical science · 2024Article
- New Solid Forms of Griseofulvin: A Solvate and a Relict Polymorph Related to Reported Solvates.Crystal growth & design · 2023Article
- Polymorphism and Multi-Component Crystal Formation of GABA and Gabapentin.Pharmaceutics · 2023Article
- Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes.IUCrJ · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The investigation of mechanical properties in molecular crystals is emerging as a novel area of interest in crystal engineering. Indeed, good mechanical properties are required to manufacture pharmaceutical and technologically relevant substances into usable products. In such endeavour, bendable single crystals help to correlate microscopic structure to macroscopic properties for potential design. The hydrate forms of two anticonvulsant zwitterionic drugs, Pregabalin and Gabapentin, are two examples of crystalline materials that show macroscopic plasticity. The direct comparison of these structures with those of their anhydrous counterparts, which are brittle, suggests that the presence of water is critical for plasticity. In contrast, structural features such as molecular packing and anisotropic distribution of strong and weak interactions seem less important.
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Registered trials
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