Evidence map›Paper›PMID 31316739›Full record

ArticleDermatology reports2019

Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris.

Oki Suwarsa, Hartati Purbo Dharmadji, Endang Sutedja, Lengga Herlina, Putri Reno Sori, Reti Hindritiani, Reiva Farah Dwiyana, Hendra Gunawan

Open access · goldAbstract read
In one paragraph

Article in Dermatology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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  15. Molecular and Cellular Mechanisms of Itch in Psoriasis.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Oki SuwarsaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Hartati Purbo DharmadjiDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Endang SutedjaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Lengga HerlinaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Putri Reno SoriDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Reti HindritianiDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Reiva Farah DwiyanaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Hendra GunawanDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Dr. Hasan Sadikin General Hospital · IDPadjadjaran University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymic stromal lymphopoietin (TSLP) is known to be associated with allergic diseases. It is also suggested that TSLP has a role in autoimmune diseases such as psoriasis; however, the associated pathways remain unknown. There is currently little information on TSLP in psoriasis vulgaris. We investigated TSLP expressions on lesional and non-lesional skin of psoriasis vulgaris patients using reverse transcription- polymerase chain reaction. TSLP level was also investigated in serum from psoriasis vulgaris patients compared to healthy control using enzyme-linked immunosorbent assay. TSLP expression was higher in lesional skin (1.90) compared to non-lesional skin (1.76); however, the difference was not statistically significant (P>0.05). TSLP serum levels were significantly higher in psoriasis patients (287.40 pg/dL) as compared to controls (114.70 pg/dL) (P<0.05). This study concluded that TSLP levels in the serum of psoriasis vulgaris patients are higher than controls. TSLP was also found in keratinocyte of psoriasis patients, the expression was higher in the lesional compared to non-lesional skin; however, this difference is statistically insignificant. These findings suggest that TSLP may play a role in the pathogenesis of psoriasis vulgaris, but its exact role remains unclear.

Indexed as

Psoriasis vulgarisSerumSkinThymic stromal lymphopoietin

Identifiers

PMID31316739
PMCPMC6600355
OpenAlexW2950191848

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.