Evidence map›Paper›PMID 31316724›Full record

ReviewComputational and structural biotechnology journal2019

Inferring Protein-Protein Interaction Networks From Mass Spectrometry-Based Proteomic Approaches: A Mini-Review.

Kumar Yugandhar, Shagun Gupta, Haiyuan Yu

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Deciphering Protein Interaction Dynamics Using the Yeast Three-Hybrid System.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
  4. Review
  5. Screening of CCDC43 molecular partners by BioID2-based proximity labeling.Turkish journal of biology = Turk biyoloji dergisi · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Protein-protein interaction prediction with deep learning: A comprehensive review.Computational and structural biotechnology journal · 2022
    Review
  11. Review
  12. Prediction of Protein Solubility Based on Sequence Feature Fusion and DDcCNN.Interdisciplinary sciences, computational life sciences · 2021
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Quantitative Mass Spectrometry-Based Proteomics: An Overview.Methods in molecular biology (Clifton, N.J.) · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kumar YugandharDepartment of Computational Biology, Cornell University, Ithaca, New York 14853, USA.
Shagun GuptaDepartment of Computational Biology, Cornell University, Ithaca, New York 14853, USA.
Haiyuan YuDepartment of Computational Biology, Cornell University, Ithaca, New York 14853, USA.

Funding

Identification and Functional Validation of Human Infertility AllelesR01HD082568 · NICHD · CORNELL UNIVERSITY · PI SCHIMENTI, JOHN C · 2015 to 2024
$6.0M
High-throughput functional characterization of human enhancersUM1HG009393 · NHGRI · CORNELL UNIVERSITY · PI LIS, JOHN T, YU, HAIYUAN · 2017 to 2021
$4.1M
Integrated high-throughput functional assays to identify ulcerative colitis causal risk variantsR01DK115398 · NIDDK · CORNELL UNIVERSITY · PI KLEIN, ROBERT J., YU, HAIYUAN · 2018 to 2022
$3.3M
Quantifying molecular consequences of human missense variants with large-scale interactome perturbation studiesR01GM125639 · NIGMS · CORNELL UNIVERSITY · PI ALEXOV, EMIL GEORGIEV, CLARK, ANDREW G · 2018 to 2021
$2.6M
Whole Genome Sequencing to Discover Familial Myeloma Risk GenesR01CA167824 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LIPKIN, STEVEN M, OFFIT, KENNETH · 2012 to 2016
$1.9M
Towards a comprehensive protein interactome network in Schizosaccharomyces pombeR01GM097358 · NIGMS · CORNELL UNIVERSITY · PI YU, HAIYUAN · 2012 to 2016
$1.7M
Using Protein Interactome Networks to Understand the Functional Role of Coding DNR01GM104424 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LIPKIN, STEVEN M, YU, HAIYUAN · 2013 to 2016
$1.7M
Towards a comprehensive multiscale 3D human interactome networkR01GM124559 · NIGMS · CORNELL UNIVERSITY · PI YU, HAIYUAN · 2017 to 2020
$1.5M
NCI NIH HHS R01 CA167824NHGRI NIH HHS UM1 HG009393NICHD NIH HHS R01 HD082568NIDDK NIH HHS R01 DK115398NIGMS NIH HHS R01 GM097358NIGMS NIH HHS R01 GM104424NIGMS NIH HHS R01 GM124559NIGMS NIH HHS R01 GM125639
6 · The paper itself

Abstract

Studying protein-protein interaction networks provide key evidence for the underlying molecular mechanisms. Mass spectrometry-based proteomic approaches have been playing a pivotal role in deciphering these interaction networks, along with precise quantification for individual interactions. In this mini-review we discuss the available techniques and methods for qualitative and quantitative elucidation of protein-protein interaction networks. We then summarize the down-stream computational strategies for identification and quantification of interactions from those techniques. Finally, we highlight the challenges and limitations of current computational pipelines in eliminating false positive interactors, followed by a summary of the innovative algorithms to address these issues, along with the scope for future improvements.

Indexed as

Interaction networkMass spectrometryProtein-proteinProteomicsSystems biology

Identifiers

PMID31316724
PMCPMC6611912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.