ReviewThe western journal of emergency medicine2019
Evaluation and Management of Angioedema in the Emergency Department.
Review in The western journal of emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 77 citations in OpenAlex.
- Medical Malpractice in the Management of Angioedema: A Multidisciplinary Westlaw Analysis.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Recurrent Bilateral Anesthesia Mumps after Cesarean Section Under Spinal Anesthesia, Rare Case Report and Literature Review.Clinical medicine insights. Case reports · 2026Article
- Article
- Impact of providing education on the recognition and differential diagnosis of angioedema among emergency department physicians.The World Allergy Organization journal · 2025Article
- Article
- Diphenhydramine: A Review of Its Clinical Applications and Potential Adverse Effect Profile.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Recurrent Intestinal Angioedema with Normal C1-Inhibitor: A Case Report.Medicina (Kaunas, Lithuania) · 2025Article
- Facial Edema After Nuclear Stress Test.Cureus · 2025Article
- Erratum: Effect of Fresh Frozen Plasma Infusion on Hospital Length of Stay for Patients With Hereditary Angioedema.Journal of health economics and outcomes research · 2025Article
- Substance Use Disorder as Risk Factor for Intubation in Angioedema: A Nationwide Cohort Study.The Laryngoscope · 2025Article
- [Algorithm for management of acute angioedema].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Thromboelastography in acute immunologic reactions: a prospective pilot study.Research and practice in thrombosis and haemostasis · 2024Article
- Five-Membered Nitrogen Heterocycles Angiotensin-Converting Enzyme (ACE) Inhibitors Induced Angioedema: An Underdiagnosed Condition.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Isolated Laryngeal Angioedema in a Patient with Long-term ACE Inhibitor Use: A Case Report.Clinical practice and cases in emergency medicine · 2024Article
- Edema of the Scrotum and Penile Shaft: An Uncommon Initial Presentation of Acquired Angioedema With Low C1-Inhibitor.Case reports in urology · 2024Article
- Angiotensin-Converting Enzyme Inhibitors and Other Medications Associated With Angioedema.Cureus · 2023Review
- Angioedema without urticaria after recent initiation of celecoxib.BMJ case reports · 2023Article
- Could it be hereditary angioedema?-Perspectives from different medical specialties.Clinical and translational allergy · 2023Review
- Bradykinin Metabolism and Drug-Induced Angioedema.International journal of molecular sciences · 2023Review
- The multifactorial impact of receiving a hereditary angioedema diagnosis.The World Allergy Organization journal · 2023Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angioedema is defined by non-dependent, non-pitting edema that affects several different sites and is potentially life-threatening due to laryngeal edema. This narrative review provides emergency physicians with a focused overview of the evaluation and management of angioedema. Two primary forms include histamine-mediated and bradykinin-mediated angioedema. Histamine-mediated forms present similarly to anaphylaxis, while bradykinin-mediated angioedema presents with greater face and oropharyngeal involvement and higher risk of progression. Initial evaluation and management should focus on evaluation of the airway, followed by obtaining relevant historical features, including family history, medications, and prior episodes. Histamine-mediated angioedema should be treated with epinephrine intramuscularly, antihistaminergic medications, and steroids. These medications are not effective for bradykinin-mediated forms. Other medications include C1-INH protein replacement, kallikrein inhibitor, and bradykinin receptor antagonists. Evidence is controversial concerning the efficacy of these medications in an acute episode, and airway management is the most important intervention when indicated. Airway intervention may require fiberoptic or video laryngoscopy, with preparation for cricothyrotomy. Disposition is dependent on patient's airway and respiratory status, as well as the sites involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.