ReviewTherapeutic advances in musculoskeletal disease2019
Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis.
Review in Therapeutic advances in musculoskeletal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Is There Any Association Between Periodontitis and Prostatic Alterations? A Systematic Review.The Prostate · 2025Pooled it
- Effects of non-surgical periodontal therapy on periodontal clinical data in periodontitis patients with rheumatoid arthritis: a meta-analysis.BMC oral health · 2021Pooled it
- Lead exposure and its association with neurological damage: systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Association Between Diabetic Retinopathy and Periodontitis-A Systematic Review.Frontiers in public health · 2020Pooled it
- Could periodontitis be associated with overall and cancer-specific mortality risk; a 35-year Swedish cohort study.Acta odontologica Scandinavica · 2025Article
- The interrelationship between periodontal disease and systemic health.British dental journal · 2025Review
- A Review of Connecting Bioinformatic Techniques to Rheumatoid Arthritis and its Associated Comorbidities.Current rheumatology reviews · 2025Review
- Omentin level in serum and gingival crevicular fluid following non-surgical periodontal therapy among Rheumatoid Arthritis patients.Bioinformation · 2025Article
- Oral Microbiome Dysbiosis and Citrullination in Rheumatoid Arthritis.Advances in experimental medicine and biology · 2025Review
- Inflammation indices in association with periodontitis and cancer.Periodontology 2000 · 2024Review
- Exploring the Bidirectional Relationship Between Periodontitis and Rheumatoid Arthritis in a Large Danish Cohort.ACR open rheumatology · 2024Article
- Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: A review of the last 10 years.The Japanese dental science review · 2023Review
- Article
- Effects of periodontitis on cancer outcomes in the era of immunotherapy.The lancet. Healthy longevity · 2023Review
- Evolving evidence for relationships between periodontitis and systemic diseases: Position paper from the Canadian Dental Hygienists Association.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2022Review
- Antimicrobial Activity ofAntibiotics (Basel, Switzerland) · 2022Article
- Does periodontal treatment improve rheumatoid arthritis disease activity? A systematic review.Rheumatology advances in practice · 2022Review
- Effects of Obesity on Bone Healing in Rats.International journal of molecular sciences · 2021Article
- Should We Be Screening for and Treating Periodontal Disease in Individuals Who Are at Risk of Rheumatoid Arthritis?Healthcare (Basel, Switzerland) · 2021Review
- No Obvious Role for Suspicious Oral Pathogens in Arthritis Development.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is an inflammatory disease of dental supporting tissues (gingiva, periodontal ligament, and bone) and it has been suggested as a possible etiology for rheumatoid arthritis (RA). In this systematic review, we aim to verify if periodontitis represents a risk factor for RA. Electronic databases were consulted until March 2018 considering eligibility criteria focusing on: (P, participants) adults; (E, exposure) with periodontitis; (C, comparison) without periodontitis; and (O, outcome) development of RA. Quality assessment of studies and risk-of-bias evaluation were also performed. To undertake a quantitative analysis, the number of persons with RA and a total number of participants for the case group (with periodontitis) and control group (without periodontitis) were used to calculate the odds ratio (OR) with a 95% confidence interval (CI). A total of 3888 articles were identified, and nine studies were considered eligible. Seven of 9 articles suggested an association among diseases by the common pro-inflammatory profiles. The pooled analysis of 3 articles showed a higher RA prevalence for persons with periodontitis (
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