Evidence map›Paper›PMID 31316548›Full record

ArticleFrontiers in genetics2019

NRXN1 Deletion and Exposure to Methylmercury Increase Astrocyte Differentiation by Different Notch-Dependent Transcriptional Mechanisms.

Marilena Raciti, Jahan Salma, Stefan Spulber, Giulia Gaudenzi, Zahra Khalajzeyqami, Mirko Conti, Britt-Marie Anderlid, Anna Falk, Ola Hermanson, Sandra Ceccatelli

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Marilena RacitiDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Jahan SalmaDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Stefan SpulberDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Giulia GaudenziDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Zahra KhalajzeyqamiDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Mirko ContiDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Britt-Marie AnderlidCentre for Molecular Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Anna FalkDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ola HermansonDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Sandra CeccatelliDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Controversial evidence points to a possible involvement of methylmercury (MeHg) in the etiopathogenesis of autism spectrum disorders (ASD). In the present study, we used human neuroepithelial stem cells from healthy donors and from an autistic patient bearing a bi-allelic deletion in the gene encoding for

Indexed as

astrogliaautism spectrum disordersmethylmercury (MeHg)neurotoxicitynotch signaling pathwayNRXN1 bi-allelic deletion

Identifiers

PMID31316548
PMCPMC6610538
OpenAlexW2952229554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.