Evidence map›Paper›PMID 31316544›Full record

ArticleFrontiers in genetics2019

The Drosophila Gene

Kevin A Hope, Daniel Flatten, Peter Cavitch, Ben May, James S Sutcliffe, Janis O'Donnell, Lawrence T Reiter

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  6. The effect of microbiome on social spacing inmicroPublication biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Kevin A HopeIntegrated Program in Biological Sciences, The University of Tennessee Health Science Center, Memphis, TN, United States.
Daniel FlattenChristian Brothers University, Memphis, TN, United States.
Peter CavitchIntegrated Program in Biological Sciences, The University of Tennessee Health Science Center, Memphis, TN, United States.
Ben MayRhodes College, Memphis, TN, United States.
James S SutcliffeDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, United States.
Janis O'DonnellDepartment of Biological Sciences, University of Alabama, Tuscaloosa, AL, United States.
Lawrence T ReiterDepartment of Neurology, The University of Tennessee Health Science Center, Memphis, TN, United States.
University of Tennessee Health Science Center · USChristian Brothers University · USRhodes College · USUniversity of Alabama · USVanderbilt University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Proteomics in Drosophila to Identify Autism Candidate Substrates of UBE3AR01NS059902 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI REITER, LAWRENCE T · 2008 to 2011
$1.3M
An in vivo chemical screen for seizure suppression in Duplication 15q syndrome.R21HD091541 · NICHD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI REITER, LAWRENCE T · 2017 to 2018
$418k
NICHD NIH HHS R21 HD091541NIH HHS P40 OD018537NINDS NIH HHS R01 NS059902
6 · The paper itself

Abstract

Major challenges to identifying genes that contribute to autism spectrum disorder (ASD) risk include the availability of large ASD cohorts, the contribution of many genes overall, and small effect sizes attributable to common gene variants. An alternative approach is to use a model organism to detect alleles that impact ASD-relevant behaviors and ask whether homologous human genes infer ASD risk. Here we utilized the Drosophila genetic reference panel (DGRP) as a tool to probe for perturbation in naturally occurring behaviors in

Indexed as

autismDGRPDrosophilaGWASheparin sulfate

Identifiers

PMID31316544
PMCPMC6611434
OpenAlexW2949547154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.