ReviewFrontiers in microbiology2019
Confirmed and Potential Roles of Bacterial T6SSs in the Intestinal Ecosystem.
Review in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 56 citations in OpenAlex.
- Bacterial weaponry and the ecological factors of competitive success.Essays in biochemistry · 2026Review
- Specific and broad-spectrum antibacterial effectors of type VI secretion system drive competition ofMicrobiology spectrum · 2026Article
- AnMicrobiology spectrum · 2026Article
- Deciphering theJournal of bacteriology · 2025Review
- Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance.Nature communications · 2025Article
- Transcriptomic profiling reveals RetS-mediated regulation of type VI secretion system and host cell responses inFrontiers in cellular and infection microbiology · 2025Article
- Salmonella enterica virulence databases and bioinformatic analysis tools development.Scientific reports · 2024Article
- Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2024Article
- Molecular characterization and in-depth genomic analysis to unravel the pathogenic features of an environmental isolate Enterobacter sp. S-33.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Selective depletion of Campylobacter jejuni via T6SS dependent functionality: an approach for improving chickens gut health.Gut pathogens · 2024Article
- Phage-Mediated Digestive Decolonization in a Gut-On-A-Chip Model: A Tale of Gut-Specific Bacterial Prosperity.Viruses · 2024Article
- Article
- The honeybee microbiota and its impact on health and disease.Nature reviews. Microbiology · 2024Review
- Trojan horselike T6SS effector TepC mediates both interference competition and exploitative competition.The ISME journal · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Community composition and the environment modulate the population dynamics of type VI secretion in human gut bacteria.Nature ecology & evolution · 2023Article
- Complete genome sequence analysis of the multidrug resistantJournal of advanced veterinary and animal research · 2023Article
- Comparative Genomic Analyses of Virulence and Antimicrobial Resistance inMicroorganisms · 2023Article
- Molecular characterization and in-depth genome analysis of Enterobacter sp. S-16.Functional & integrative genomics · 2023Article
- Collective protection against the type VI secretion system in bacteria.The ISME journal · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contact-dependent type VI secretion system (T6SS) in diverse microbes plays crucial roles in both inter-bacterial and bacteria-host interactions. As numerous microorganisms inhabit the intestinal ecosystem at a high density, it is necessary to consider the functions of T6SS in intestinal bacteria. In this mini-review, we discuss T6SS-dependent functions in intestinal microbes, including commensal microbes and enteric pathogens, and list experimentally verified species of intestinal bacteria containing T6SS clusters. Several seminal studies have shown that T6SS plays crucial antibacterial roles in colonization resistance, niche occupancy, activation of host innate immune responses, and modulation of host intestinal mechanics. Some potential roles of T6SS in the intestinal ecosystem, such as targeting of single cell eukaryotic competitors, competition for micronutrients, and stress resistance are also discussed. Considering the distinct activities of T6SS in diverse bacteria residing in the intestine, we suggest that T6SS research in intestinal microbes may be beneficial for the future development of new medicines and clinical treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.