Evidence map›Paper›PMID 31316461›Full record

ReviewFrontiers in endocrinology2019

Management of Women With an Unexpected Low Ovarian Response to Gonadotropin.

Alessandro Conforti, Sandro C Esteves, Danilo Cimadomo, Alberto Vaiarelli, Francesca Di Rella, Filippo Maria Ubaldi, Fulvio Zullo, Giuseppe De Placido, Carlo Alviggi

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05298657 (The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment), which is not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05298657 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment

Typeobservational_patient_registrySponsorFatima College of Health SciencesRan2022 to 2024Enrolled200ConditionsPoor Response to Ovulation Induction, PCOS, Endometriosis, Infertility, Female
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Alessandro ConfortiDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Sandro C EstevesANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil.
Danilo CimadomoGENERA, Centre for Reproductive Medicine, Clinica Valle Giulia, Rome, Italy.
Alberto VaiarelliGENERA, Centre for Reproductive Medicine, Clinica Valle Giulia, Rome, Italy.
Francesca Di RellaMedical Oncology, Department of Senology, National Cancer Institute, IRCCS Fondazione G. Pascale, Naples, Italy.
Filippo Maria UbaldiGENERA, Centre for Reproductive Medicine, Clinica Valle Giulia, Rome, Italy.
Fulvio ZulloDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Giuseppe De PlacidoDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Carlo AlviggiDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
University of Naples Federico II · ITClinica Valle Giulia · ITAarhus University · DKIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

POSEIDON groups 1 and 2 patients respond poorly (<4 oocytes retrieved) or sub-optimally (4-9 oocytes retrieved) to gonadotropin stimulation despite the presence of adequate ovarian parameters, which negatively affect their cumulative chances of delivering a baby using Assisted Reproductive Technology. A polygenic trait involving gonadotropins and/or their receptors seems to be the primary pathophysiology mechanism explaining this phenomenon. The clinical management is mainly focused on maximizing oocyte yield as to increase the likelihood of having at least one euploid embryo for transfer. Indices such as FORT (follicle output rate) and FOI (follicle-to-oocyte index) may be used to determine if the ovarian reserve was properly explored during a previous ovarian stimulation. Testing for the presence of common polymorphisms affecting gonadotropins and/or their receptors can also be considered to identify patients at risk of hypo-response. An individualized estimation of the minimum number of oocytes needed to obtain at least one euploid embryo can assist counseling and treatment planning. Among currently existing pharmacological interventions, use of recombinant FSH in preference over urinary gonadotropin preparations, FSH dosage increase, and use of rLH supplementation may be considered -alone or combined- for optimally managing POSEIDON's groups 1 and 2 patients. However, given the recent introduction of the POSEIDON criteria, there is still a lack of studies examining the role of interventions specifically to patients classified as groups 1 and 2, thus making it an area for open research.

Indexed as

ART calculatorAssisted Reproductive Technologyfollicle-to-oocyte indexhypo-responseovarian reserveovarian stimulationPOSEIDON criteriasuboptimal response

Identifiers

PMID31316461
PMCPMC6610322
OpenAlexW2954186275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.