ArticleFrontiers in pharmacology2019
The Novel Atypical Dopamine Uptake Inhibitor
Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.Neuroscience and biobehavioral reviews · 2026Review
- Theta oscillations vary with local response rate and are moderated by the dopamine-depleting agent, tetrabenazine, during effort-based behavior.Cognitive, affective & behavioral neuroscience · 2026Article
- Dopamine antagonist effects of the D2/D3 receptor partial agonist aripiprazole on effort-based choice tasks in male and female rats.Cognitive, affective & behavioral neuroscience · 2026Article
- Impact of brief maternal separation on rodent models of anergia induced by dopamine depletion: analysis in mice of both sexes during adulthood.Psychopharmacology · 2025Article
- Unlocking the Potential of High-Quality Dopamine Transporter Pharmacological Data: Advancing Robust Machine Learning-Based QSAR Modeling.Advances in neurobiology · 2025Review
- Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Article
- Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor.International journal of molecular sciences · 2024Article
- The Atypical Dopamine Transporter Inhibitor CE-158 Enhances Dopamine Neurotransmission in the Prefrontal Cortex of Male Rats: A Behavioral, Electrophysiological, and Microdialysis Study.The international journal of neuropsychopharmacology · 2023Article
- Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry.Biomolecules · 2023Article
- Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat.Biomolecules · 2023Article
- A Novel and Selective Dopamine Transporter Inhibitor,Biomolecules · 2022Article
- The influence of reinforcement schedule on experience-dependent changes in motivation.Journal of the experimental analysis of behavior · 2022Article
- Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding.Journal of the experimental analysis of behavior · 2022Article
- The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice.Biomolecules · 2022Article
- Increased elasticity of sucrose demand during hyperdopaminergic states in rats.Psychopharmacology · 2022Article
- Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats.Scientific reports · 2021Article
- Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition.Molecular psychiatry · 2021Article
- Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal studies of effort-based choice behavior are being used to model effort-related motivational dysfunctions in humans. With these procedures, animals are offered a choice between high-effort instrumental actions leading to highly valued reinforcers vs. low effort/low reward options. Several previous studies have shown that dopamine (DA) uptake inhibitors, including GBR12909, lisdexamfetamine, methylphenidate, and PRX-14040, can reverse the effort-related effects of the vesicular monoamine transport blocker tetrabenazine, which inhibits DA storage. Because many drugs that block DA transport act as major stimulants that also release DA, and produce a number of undesirable side effects, there is a need to develop and characterize novel atypical DA transport inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.