ArticleFrontiers in aging neuroscience2019
Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- An Activation Likelihood Estimation Meta-Analysis of Specific Functional Alterations in Dorsal Attention Network in Mild Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Convergent functional changes of the episodic memory impairment in mild cognitive impairment: An ALE meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Examining the Effects of Bright Light Therapy on Sleep and Resting-State Brain Activity in Parkinson's Disease: A Randomized Crossover Pilot Study.Nature and science of sleep · 2026Trial
- Sex differences in brain activity and connectivity in late-life depression.Psychoradiology · 2026Article
- Stage-specific functional networks associated with cognitive impairment in Parkinson's disease: a pilot fNIRS study.Frontiers in aging neuroscience · 2025Article
- A potential brain functional biomarker distinguishing patients with Crohn's disease with different disease stages: a resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Disruptive and complementary effects of depression symptoms on spontaneous brain activity in the subcortical vascular mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study.Frontiers in neurology · 2023Article
- Dynamic brain activity states of memory impairment in stroke patients with varying motor outcomes.Frontiers in aging neuroscience · 2023Article
- Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss.Frontiers in neuroscience · 2023Article
- Shared and specific dynamics of brain activity and connectivity in amnestic and nonamnestic mild cognitive impairment.CNS neuroscience & therapeutics · 2022Article
- From Molecular to Behavior: Higher Order Occipital Cortex in Major Depressive Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Dynamic changes in fractional amplitude of low-frequency fluctuations in patients with chronic insomnia.Frontiers in neuroscience · 2022Article
- Percentage amplitude of fluctuation and structural covariance changes of subjective cognitive decline in patients: A multimodal imaging study.Frontiers in neuroscience · 2022Article
- Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease.Neuropsychiatric disease and treatment · 2021Article
- Altered Temporal Dynamic Intrinsic Brain Activity in Late Blindness.BioMed research international · 2020Article
- Abnormal Static and Dynamic Local-Neural Activity in COPD and Its Relationship With Pulmonary Function and Cognitive Impairments.Frontiers in human neuroscience · 2020Article
- Network change point detection in resting-state functional connectivity dynamics of mild cognitive impairment patients.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies investigating working memory performance in patients with mild cognitive impairment (MCI) have mainly focused on the neural mechanisms of alterations in activation. To date, very few studies have investigated background network alterations in the working memory state. Therefore, the present study investigated the static and temporal dynamic changes in the background network in MCI patients during a working memory task. A hybrid delayed-match-to-sample task was used to examine working memory performance in MCI patients. Functional magnetic resonance imaging (fMRI) data were collected and the marker of amplitude of low-frequency fluctuations (ALFF) was used to investigate alterations in the background network. The present study demonstrated static and dynamic alterations of ALFF in MCI patients during working memory tasks, relative to the resting state. Traditional static analysis revealed that ALFF decreased in the right ventrolateral prefrontal cortex (VLPFC), right dorsolateral PFC (DLPFC), and left supplementary motor area for normal controls (NCs) in the working memory state. However, the same regions showed increased ALFF in MCI patients. Furthermore, relative to NCs, MCI patients demonstrated altered performance-related functional connectivity (FC) patterns, with the right VLPFC and right DLPFC as ROIs. In terms of temporal dynamic analysis, the present study found that in the working memory state dynamic ALFF of bilateral thalamus regions was increased in NCs but decreased in MCI patients. Additionally, MCI patients demonstrated altered performance-related coefficient of variation patterns; the regions in MCI patients were larger and more widely distributed in the parietal and temporal lobes, relative to NCs. This is the first study to examine static and temporal dynamic alterations of ALFF in the background network of MCI patients in working memory states. The results extend previous studies by providing a new perspective on the neural mechanisms of working memory deficits in MCI patients.
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