ReviewFrontiers in cellular neuroscience2019
The Median Nerve Injury Model in Pre-clinical Research - A Critical Review on Benefits and Limitations.
Review in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of studies comparing muscle-in-vein conduits with autologous nerve grafts for nerve reconstruction.Scientific reports · 2021Pooled it
- Long-term exploratory evaluation of an acellular biomimetic polyfascicular nerve guidance conduit for peripheral nerve repair in a rhesus macaque model.Bioactive materials · 2027Article
- Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.Neural regeneration research · 2026Article
- Stem cell-derived secretome and dental pulp stem cells enhance sciatic nerve regeneration in a rat sciatic neurotmesis model using chitosan nerve conduits.Frontiers in cell and developmental biology · 2026Article
- Standardization of a Supramaximal Stimulation Protocol for Electrophysiological Assessment of the Intact Rat Median Nerve.BioMed research international · 2026Article
- What Is the Sequence of Mechanical and Structural Failure During Stretch Injury in the Rat Median Nerve? The Neuroclasis Classification.Clinical orthopaedics and related research · 2025Article
- The course of mechanical allodynia differs between forelimb innervation territories following median nerve injury in the rat.Frontiers in neuroscience · 2025Article
- Distal Nerve Transfer for Opponensplasty in the Setting of High Median Nerve Injury: A Case Series.Advances in orthopedics · 2025Article
- Morphological Methods to Evaluate Peripheral Nerve Fiber Regeneration: A Comprehensive Review.International journal of molecular sciences · 2023Review
- The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury.Biomedicines · 2022Review
- ESWT Diminishes Axonal Regeneration following Repair of the Rat Median Nerve with Muscle-In-Vein Conduits but Not after Autologous Nerve Grafting.Biomedicines · 2022Article
- Review
- Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes.Bioengineering & translational medicine · 2021Article
- Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring.Journal of clinical medicine · 2021Review
- Establishment of a Sheep Model for Hind Limb Peripheral Nerve Injury: Common Peroneal Nerve.International journal of molecular sciences · 2021Article
- Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration.Bioengineering (Basel, Switzerland) · 2020Review
- Modification of tubular chitosan-based peripheral nerve implants: applications for simple or more complex approaches.Neural regeneration research · 2020Review
- UV-Casting on Methacrylated PCL for the Production of a Peripheral Nerve Implant Containing an Array of Porous Aligned Microchannels.Polymers · 2020Article
- Immediate or Delayed Transplantation of a Vein Conduit Filled with Nasal Olfactory Stem Cells Improves Locomotion and Axogenesis in Rats after a Peroneal Nerve Loss of Substance.International journal of molecular sciences · 2020Article
- Evaluation of Functional Recovery in Rats After Median Nerve Resection and Autograft Repair Using Computerized Gait Analysis.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The successful introduction of innovative treatment strategies into clinical practise strongly depends on the availability of effective experimental models and their reliable pre-clinical assessment. Considering pre-clinical research for peripheral nerve repair and reconstruction, the far most used nerve regeneration model in the last decades is the sciatic nerve injury and repair model. More recently, the use of the median nerve injury and repair model has gained increasing attention due to some significant advantages it provides compared to sciatic nerve injury. Outstanding advantages are the availability of reliable behavioural tests for assessing posttraumatic voluntary motor recovery and a much lower impact on the animal wellbeing. In this article, the potential application of the median nerve injury and repair model in pre-clinical research is reviewed. In addition, we provide a synthetic overview of a variety of methods that can be applied in this model for nerve regeneration assessment. This article is aimed at helping researchers in adequately adopting this
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