Evidence map›Paper›PMID 31316338›Full record

ArticleFrontiers in neuroscience2019

A Putative Role of Teneurin-2 and Its Related Proteins in Astrocytes.

Gestter W L Tessarin, Ola M Michalec, Kelly R Torres-da-Silva, André V Da Silva, Roelf J Cruz-Rizzolo, Alaide Gonçalves, Daniele C Gasparini, José A C Horta-Júnior, Edilson Ervolino, Jackson C Bittencourt and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  8. Improvements in operant memory ofFrontiers in behavioral neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Gestter W L TessarinDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.
Ola M MichalecDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Kelly R Torres-da-SilvaDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.
André V Da SilvaDepartment of Anatomy, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, Brazil.
Roelf J Cruz-RizzoloDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.
Alaide GonçalvesDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.
Daniele C GaspariniDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.
José A C Horta-JúniorDepartment of Anatomy, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, Brazil.
Edilson ErvolinoDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.
Jackson C BittencourtDepartment of Anatomy, Institute of Biomedical Sciences, São Paulo University (USP), São Paulo, Brazil.
David A LovejoyDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Cláudio A CasattiDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversity of Toronto · CAUniversidade Federal de Mato Grosso do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teneurins are type II transmembrane proteins comprised of four phylogenetically conserved homologs (Ten-1-4) that are highly expressed during neurogenesis. An additional bioactive peptide named teneurin C-terminal-associated peptide (TCAP-1-4) is present at the carboxyl terminal of teneurins. The possible correlation between the Ten/TCAP system and brain injuries has not been explored yet. Thus, this study examined the expression of these proteins in the cerebral cortex after mechanical brain injury. Adult rats were subjected to cerebral cortex injury by needle-insertion lesion and sacrificed at various time points. This was followed by analysis of the lesion area by immunohistochemistry and conventional RT-PCR techniques. Control animals (no brain injury) showed only discrete Ten-2-like immunoreactive pyramidal neurons in the cerebral cortex. In contrast, Ten-2 immunoreactivity was significantly up-regulated in the reactive astrocytes in all brain-injured groups (

Indexed as

adult ratcerebral cortexlatrophilinmechanical brain injuryreactive astrocytesteneurinteneurin c-terminal associated peptide

Identifiers

PMID31316338
PMCPMC6609321
OpenAlexW2955994023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.