Evidence map›Paper›PMID 31316210›Full record

ArticleNature2019

Conformation space of a heterodimeric ABC exporter under turnover conditions.

Susanne Hofmann, Dovile Januliene, Ahmad R Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T Kuhn, Eric R Geertsma, Gerhard Hummer, Robert Tampé and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 252 citations in OpenAlex.

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  5. A dual sensor regulates P-glycoprotein's structural plasticity.bioRxiv : the preprint server for biology · 2026
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  11. Molecular mechanism of substrate transport by human peroxisomal ABCD3.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  13. Article
  14. Article
  15. Article
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  18. Article
  19. Article
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Susanne Hofmann *Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
Dovile Januliene *Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
Ahmad R Mehdipour *Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
Christoph ThomasInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
Erich StefanInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
Stefan BrüchertInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
Benedikt T KuhnInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
Eric R GeertsmaInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
Gerhard HummerDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
Robert TampéInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany. tampe@em.uni-frankfurt.de.
Arne MoellerDepartment of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany. arne.moeller@biophys.mpg.de.
Goethe University Frankfurt · DEMax Planck Institute of Biophysics · DE

Funding

European Research Council 789121
6 · The paper itself

Abstract

Cryo-electron microscopy (cryo-EM) has the capacity to capture molecular machines in action

Indexed as

Cryoelectron MicroscopyAdenosine DiphosphateAdenosine TriphosphateATP-Binding Cassette TransportersHydrolysisKineticsModels, MolecularMutationProtein ConformationProtein MultimerizationSubstrate SpecificityThermus thermophilusVanadatesAdenosine DiphosphateAdenosine TriphosphateATP-Binding Cassette TransportersVanadates

Identifiers

PMID31316210
PMCPMC7612745
OpenAlexW2957093526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.