ArticleScientific reports2019
Measuring vision using innate behaviours in mice with intact and impaired retina function.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Split-spectrum amplitude decorrelation optoretinography for functional imaging of mouse photoreceptors.Biomedical optics express · 2026Article
- Quantifying functional vision in a mouse model of oculocutaneous albinism type 1.Scientific reports · 2026Article
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
- The visual evoked potential is a sensitive and powerful measure of experience-dependent visual cortical plasticity in mice.Current opinion in neurobiology · 2025Review
- Altered proportions of retinal cell types and distinct visual codes in rodents occupying divergent ecological niches.Current biology : CB · 2025Article
- Age-Related RPE changes in Wildtype C57BL/6J Mice between 2 and 32 Months.bioRxiv : the preprint server for biology · 2024Article
- CX3CL1/CX3CR1 Signaling Mediated Neuroglia Activation Is Implicated in the Retinal Degeneration: A Potential Therapeutic Target to Prevent Photoreceptor Death.Investigative ophthalmology & visual science · 2024Article
- Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model.Pharmaceutics · 2023Article
- Three-dimensional unsupervised probabilistic pose reconstruction (3D-UPPER) for freely moving animals.Scientific reports · 2023Article
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- Look-up and look-down neurons in the mouse visual thalamus during freely moving exploration.Current biology : CB · 2022Article
- Effect of Retinal Injury Induced by Laser Photocoagulation on Visuospatial Memory in Mouse Model.Journal of neurosciences in rural practice · 2021Article
- HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice.Cell death and differentiation · 2021Article
- Pupillary reflex and behavioral masking responses to light as functional measures of retinal degeneration in mice.PloS one · 2021Article
- A High-Dimensional Quantification of Mouse Defensive Behaviors Reveals Enhanced Diversity and Stimulus Specificity.Current biology : CB · 2020Article
- Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner.ASN neuroArticle
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Measuring vision in rodents is a critical step for understanding vision, improving models of human disease, and developing therapies. Established behavioural tests for perceptual vision, such as the visual water task, rely on learning. The learning process, while effective for sighted animals, can be laborious and stressful in animals with impaired vision, requiring long periods of training. Current tests that that do not require training are based on sub-conscious, reflex responses (e.g. optokinetic nystagmus) that don't require involvement of visual cortex and higher order thalamic nuclei. A potential alternative for measuring vision relies on using visually guided innate defensive responses, such as escape or freeze, that involve cortical and thalamic circuits. In this study we address this possibility in mice with intact and degenerate retinas. We first develop automatic methods to detect behavioural responses based on high dimensional tracking and changepoint detection of behavioural time series. Using those methods, we show that visually guided innate responses can be elicited using parametisable stimuli, and applied to describing the limits of visual acuity in healthy animals and discriminating degrees of visual dysfunction in mouse models of retinal degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.