ArticleNature communications2019
Label-free neuroimaging in vivo using synchronous angular scanning microscopy with single-scattering accumulation algorithm.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
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- Performance enhancement in wavefront shaping of multiply scattered light: a review.Journal of biomedical optics · 2024Review
- Label-free adaptive optics single-molecule localization microscopy for whole zebrafish.Nature communications · 2023Article
- Exploiting volumetric wave correlation for enhanced depth imaging in scattering medium.Nature communications · 2023Article
- Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin.Nature communications · 2023Article
- Recent advances in optical imaging through deep tissue: imaging probes and techniques.Biomaterials research · 2022Review
- Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues.Nature communications · 2022Article
- Through-skull brain imaging in vivo at visible wavelengths via dimensionality reduction adaptive-optical microscopy.Science advances · 2022Article
- High-throughput volumetric adaptive optical imaging using compressed time-reversal matrix.Light, science & applications · 2022Article
- Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Laser scanning reflection-matrix microscopy for aberration-free imaging through intact mouse skull.Nature communications · 2020Article
- Label-free microendoscopy using a micro-needle imaging probe forBiomedical optics express · 2020Article
- Distortion matrix concept for deep optical imaging in scattering media.Science advances · 2020Article
- Distortion matrix approach for ultrasound imaging of random scattering media.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Quantitative phase and polarization imaging through an optical fiber applied to detection of early esophageal tumorigenesis.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Label-free in vivo imaging is crucial for elucidating the underlying mechanisms of many important biological systems in their most native states. However, the applicability of existing modalities has been limited to either superficial layers or early developmental stages due to tissue turbidity. Here, we report a synchronous angular scanning microscope for the rapid interferometric recording of the time-gated reflection matrix, which is a unique matrix characterizing full light-specimen interaction. By applying single scattering accumulation algorithm to the recorded matrix, we removed both high-order sample-induced aberrations and multiple scattering noise with the effective aberration correction speed of 10,000 modes/s. We demonstrated in vivo imaging of whole neural network throughout the hindbrain of the larval zebrafish at a matured stage where physical dissection used to be required for conventional imaging. Our method will expand the scope of applications for optical imaging, where fully non-invasive interrogation of living specimens is critical.
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