ArticleNature communications2019
The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- A TCER-1-siRNA regulatory axis suppresses antibacterial innate immunity in C. elegans.PLoS pathogens · 2026Article
- LIPL-1 and LIPL-2 are TCER-1-regulated lysosomal lipases with distinct roles in immunity and fertility.PLoS genetics · 2025Article
- Article
- Antiaging Effect of 2-Foods (Basel, Switzerland) · 2025Article
- HLH-30/TFEB mediates sexual dimorphism in immunity inAutophagy · 2025Article
- Calcineurin inhibition enhanceseLife · 2024Article
- ADARs regulate cuticle collagen expression and promote survival to pathogen infection.BMC biology · 2024Article
- Decoding lifespan secrets: the role of the gonad inFrontiers in aging · 2024Review
- The Role of mRNA Quality Control in the Aging ofMolecules and cells · 2023Review
- Amphid sensory neurons ofLife science alliance · 2023Article
- Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response.Nature communications · 2023Article
- Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity.Aging cell · 2023Article
- A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway.Frontiers in immunology · 2023Article
- Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling inMolecules and cells · 2022Review
- Article
- Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30.Cell reports · 2021Article
- A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response.GeroScience · 2021Article
- Detection of Pathogens and Regulation of Immunity by the Caenorhabditis elegans Nervous System.mBio · 2021Review
- The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Review
- Immunometabolism in Caenorhabditis elegans.PLoS pathogens · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Stress resistance and longevity are positively correlated but emerging evidence indicates that they are physiologically distinct. Identifying factors with distinctive roles in these processes is challenging because pro-longevity genes often enhance stress resistance. We demonstrate that TCER-1, the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, has opposite effects on lifespan and stress resistance. We previously showed that tcer-1 promotes longevity in germline-less C. elegans and reproductive fitness in wild-type animals. Surprisingly, tcer-1 mutants exhibit exceptional resistance against multiple stressors, including infection by human opportunistic pathogens, whereas, TCER-1 overexpression confers immuno-susceptibility. TCER-1 inhibits immunity only during fertile stages of life. Elevating its levels ameliorates the fertility loss caused by infection, suggesting that TCER-1 represses immunity to augment fecundity. TCER-1 acts through repression of PMK-1 as well as PMK-1-independent factors critical for innate immunity. Our data establish key roles for TCER-1 in coordinating immunity, longevity and fertility, and reveal mechanisms that distinguish length of life from functional aspects of aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.