Evidence map›Paper›PMID 31316037›Full record

Trial reportAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2019

A Double-Blind Randomized Controlled Trial to Determine the Preventive Effect of Hangekobokuto on Aspiration Pneumonia in Patients Undergoing Cardiovascular Surgery.

Koji Kawago, Toshiya Nishibe, Shunya Shindo, Hidenori Inoue, Shinya Motohashi, Junetsu Akasaka, Hitoshi Ogino

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Koji KawagoDepartment of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.
Toshiya NishibeDepartment of Cardiovascular Surgery, Tokyo Medical University, Tokyo, Japan.
Shunya ShindoDepartment of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.
Hidenori InoueDepartment of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.
Shinya MotohashiDepartment of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.
Junetsu AkasakaDepartment of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.
Hitoshi OginoDepartment of Cardiovascular Surgery, Tokyo Medical University, Tokyo, Japan.
Tokyo Medical University Hachioji Medical Center · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to assess whether hangekobokuto (HKT) can prevent aspiration pneumonia in patients undergoing cardiovascular surgery.

methodsWe performed a single-center, double-blinded, randomized, placebo-controlled study of HKT in patients undergoing cardiovascular surgery. JPS HKT extract granule (JPS-16) was used as HKT. The primary endpoint was defined as the prevention of postoperative aspiration pneumonia. The secondary endpoints included complete recovery from swallowing and coughing disorders.

resultsBetween August 2014 and August 2015, a total of 34 patients were registered in this study. The rate of subjects with postoperative aspiration pneumonia was significantly lower in the HKT group than in the placebo group (p = 0.017). In high-risk patients for aspiration pneumonia, the rate was significantly lower in the HKT group than in the placebo group (p = 0.015). The rate of subjects with swallowing disorders tended to be lower in the HKT group than in the placebo group (p = 0.091), and in high-risk patients, the rate was significantly lower in the HKT group than in the placebo group (p = 0.038).

conclusionsHKT can prevent aspiration pneumonia in patients undergoing cardiovascular surgery. In high-risk patients for aspiration pneumonia, HKT can prevent aspiration pneumonia and improve swallowing disorders.

Indexed as

Medicine, KampoAgedAged, 80 and overCardiovascular Surgical ProceduresDeglutitionDeglutition DisordersDouble-Blind MethodFemaleHumansMaleMiddle AgedPlant ExtractsPneumonia, AspirationRisk FactorsTime FactorsTokyoPlant Extractsaspiration pneumoniadysphagiahangekobokutoKampo medicine

Identifiers

PMID31316037
PMCPMC6923725
OpenAlexW2957627986

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.