ArticleScience translational medicine2019
A multimodality test to guide the management of patients with a pancreatic cyst.
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In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
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86citing papers in PubMed, 4 pooled it
9.3field-weighted citation impact, top 1% of its field
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Who cites it
86 citing papers in PubMed, 4 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- High Burden of Pancreatic Surgery for Intraductal Papillary Mucinous Neoplasia With Low-Grade Dysplasia and Benign Cysts: A Systematic Review and Meta-Analysis.United European gastroenterology journal · 2026Pooled it
- The role of artificial intelligence in pancreatic surgery: a systematic review.Updates in surgery · 2022Pooled it
- Machine learning to guide clinical decision-making in abdominal surgery-a systematic literature review.Langenbeck's archives of surgery · 2022Pooled it
- Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.Virchows Archiv : an international journal of pathology · 2021Pooled it
- Discordant pathology following pancreatoduodenectomy for suspected intraductal papillary mucinous neoplasm: reassessment of cyst fluid genetic analysis.Journal of surgical case reports · 2026Article
- Article
- Cytology andJournal of clinical medicine · 2026Article
- Role of Endoscopic Ultrasonography in Management of Pancreaticobiliary Cancers: Recent Trends and Advances.Cancers · 2026Review
- PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study.Annals of surgical oncology · 2026Article
- Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia.Science advances · 2026Article
- DIAGNOSIS AND MANAGEMENT OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS: A NARRATIVE REVIEW BASED ON INTERNATIONAL GUIDELINES.Arquivos de gastroenterologia · 2026Review
- Signet-ring cell carcinoma of the appendix presenting as diffuse uterine involvement: a case report and literature review.Frontiers in oncology · 2026Article
- Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct patterns and potential markers of progression.Cancer cell · 2025Article
- Evaluating the prognostic efficacy of biomarkers in pancreatic cyst fluid.World journal of gastrointestinal endoscopy · 2025Review
- Challenges of early detection of pancreatic cancer.The Journal of clinical investigation · 2025Review
- Article
- Deciphering pancreatobiliary intraductal oncocytic papillary neoplasms: integrative analysis of histomorphologic patterns, immunophenotypic markers, and emerging molecular biomarkers.World journal of surgical oncology · 2025Review
- Single GNAS Droplet-Based Digital Polymerase Chain Reaction Analysis of Pancreatic Cyst Fluid: An Effective Up-Front Strategy for Mucinous Cyst Diagnosis by Endoscopic Ultrasound-Guided Fine-Needle Aspiration.Clinical and translational gastroenterology · 2025Article
- Alignment-free unique molecular identifier clustering suppresses sequencing errors for accurate detection of low-frequency DNA variants.Briefings in bioinformatics · 2025Article
- Application of Artificial Intelligence in Pancreatic Cyst Management: A Systematic Review.Cancers · 2025Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
60 authors at 20 institutions in 8 countries.
Simeon SpringerLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-2891-2111
David L MasicaSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.
Marco Dal MolinSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-1581-3576
Christopher DouvilleLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-2510-4151
Christopher J ThoburnLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0001-7743-9183
Bahman AfsariSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0001-8717-7199
Lu LiLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-1920-4965
Joshua D CohenLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-1158-5668
Elizabeth ThompsonSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-4633-843X
Peter J AllenDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
David S KlimstraDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Mark A SchattnerDepartment of Gastroenterology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
C Max SchmidtDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-2447-2128
Michele Yip-SchneiderDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7569-7971
Rachel E SimpsonDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Carlos Fernandez-Del CastilloDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Mari Mino-KenudsonDepartment of Histopathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-9092-2265
William BruggeDepartment of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-9119-5170
Randall E BrandDepartment of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.ORCID 0000-0002-4136-3313
Aatur D SinghiDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Aldo ScarpaARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, Italy.ORCID 0000-0003-1678-739X
Rita LawlorARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, Italy.ORCID 0000-0003-3160-0634
Roberto SalviaGeneral and Pancreatic Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy.ORCID 0000-0002-3514-8473
Giuseppe ZamboniDepartment of Pathology, Ospedale Sacro Cuore-Don Calabria, Negrar 37024, Italy.ORCID 0000-0001-7428-4673
Seung-Mo HongDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.ORCID 0000-0002-8888-6007
Dae Wook HwangHepatobiliary and Pancreas Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.ORCID 0000-0002-1749-038X
Jin-Young JangDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.ORCID 0000-0003-3312-0503
Wooil KwonDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.ORCID 0000-0002-4827-7805
Niall SwanDepartment of Histopathology, St. Vincent's University Hospital, Dublin D04 T6F4, Ireland.ORCID 0000-0003-2838-6972
Justin GeogheganDepartment of Surgery, St. Vincent's University Hospital, Dublin D04 T6F4, Ireland.ORCID 0000-0003-0266-3732
Massimo FalconiDivision of Pancreatic Surgery, Department of Surgery, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
Stefano CrippaDivision of Pancreatic Surgery, Department of Surgery, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
Claudio DoglioniDepartment of Pathology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.ORCID 0000-0002-4969-5216
Jorge PaulinoDepartment of Surgery, Centro Hepatobiliopancreático e Transplantação, Hospital Curry Cabral, Lisbon 1050-099, Portugal.ORCID 0000-0002-8491-2802
Richard D SchulickDepartment of Surgery, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0001-7360-7338
Barish H EdilDepartment of Surgery, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0003-1467-9723
Walter ParkDepartment of Medicine, Stanford University Medical Center, Palo Alto, CA 94304, USA.
Shinichi YachidaDepartment of Hepatobiliary and Pancreatic Surgery, Pathology and Cancer Genomics, National Cancer Center Hospital and National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Susumu HijiokaDepartment of Gastroenterology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.ORCID 0000-0002-0394-6876
Jeanin van HooftDepartment of Gastroenterology and Hepatology, Amsterdam Medical Center, Amsterdam 1017 ZX, Netherlands.
Jin HeDepartment of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.
Matthew J WeissDepartment of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.
Richard BurkhartDepartment of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.
Martin MakaryDepartment of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.
Marcia I CantoDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Michael G GogginsSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-4286-2296
Janine PtakLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-1934-8739
Lisa DobbynLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-3159-189X
Joy SchaeferLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0001-6788-8989
Natalie SillmanLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-5198-9037
Maria PopoliLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-2151-7749
Alison P KleinLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-2737-8399
Cristian TomasettiSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA. bertvog@gmail.com amlennon@jhmi.edu cwolfga2@jhmi.edu rhruban@jhmi.edu ctomasetti@jhu.edu karchin@jhu.edu.ORCID 0000-0003-3277-4804
Rachel KarchinDepartment of Biomedical Engineering, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-5069-1239
Nickolas PapadopoulosLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0001-7135-7451
Kenneth W KinzlerLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0001-5591-1176
Bert VogelsteinLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA. bertvog@gmail.com amlennon@jhmi.edu cwolfga2@jhmi.edu rhruban@jhmi.edu ctomasetti@jhu.edu karchin@jhu.edu.ORCID 0000-0003-0766-3854
Christopher L WolfgangSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA. bertvog@gmail.com amlennon@jhmi.edu cwolfga2@jhmi.edu rhruban@jhmi.edu ctomasetti@jhu.edu karchin@jhu.edu.ORCID 0000-0002-8717-0373
Ralph H HrubanSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-4554-5672
Anne Marie LennonLudwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA. bertvog@gmail.com amlennon@jhmi.edu cwolfga2@jhmi.edu rhruban@jhmi.edu ctomasetti@jhu.edu karchin@jhu.edu.ORCID 0000-0001-8957-3945
Howard Hughes Medical Institute · USJohns Hopkins University · USIndiana University School of MedicineMemorial Sloan Kettering Cancer Center · USVita-Salute San Raffaele University · ITCancer Research Institute · USMassachusetts General Hospital · USSt. Vincent's University Hospital · IEUniversity of Colorado Anschutz Medical Campus · USUniversity of Pittsburgh · USUniversity of Verona · ITAichi Cancer Center · JPAmsterdam UMC Location University of Amsterdam · NLAsan Medical Center · KRHarvard University · USHospital Curry Cabral · PTNational Cancer Centre Japan · JPOspedale Sacro Cuore Don Calabria · ITPancreas Centre (Canada) · CAStanford Medicine · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6MMedical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MUsing markers to improve pancreatic cancer screening and surveillance: a multi-center studyU01CA210170 · NCI · JOHNS HOPKINS UNIVERSITY · PI Michael G. Goggins · 2016 to 2026
$9.3MUsing Markers to Improve Pancreatic Cancer ScreeningR01CA176828 · NCI · JOHNS HOPKINS UNIVERSITY · PI GOGGINS, MICHAEL G. · 2013 to 2024
$4.1MNCI NIH HHS P30 CA008748NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA176828NCI NIH HHS U01 CA210170NIGMS NIH HHS T32 GM136577
Abstract
Pancreatic cysts are common and often pose a management dilemma, because some cysts are precancerous, whereas others have little risk of developing into invasive cancers. We used supervised machine learning techniques to develop a comprehensive test, CompCyst, to guide the management of patients with pancreatic cysts. The test is based on selected clinical features, imaging characteristics, and cyst fluid genetic and biochemical markers. Using data from 436 patients with pancreatic cysts, we trained CompCyst to classify patients as those who required surgery, those who should be routinely monitored, and those who did not require further surveillance. We then tested CompCyst in an independent cohort of 426 patients, with histopathology used as the gold standard. We found that clinical management informed by the CompCyst test was more accurate than the management dictated by conventional clinical and imaging criteria alone. Application of the CompCyst test would have spared surgery in more than half of the patients who underwent unnecessary resection of their cysts. CompCyst therefore has the potential to reduce the patient morbidity and economic costs associated with current standard-of-care pancreatic cyst management practices.
Indexed as
AlgorithmsAgedFemaleHumansMachine LearningMaleMiddle AgedPancreatic Cyst
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