Evidence map›Paper›PMID 31315990›Full record

ArticleJournal of virology2019

Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8

Shaheed A Abdulhaqq, Helen Wu, John B Schell, Katherine B Hammond, Jason S Reed, Alfred W Legasse, Michael K Axthelm, Byung S Park, Aravind Asokan, Klaus Früh and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Identification and Characterization of Antigen-Specific CD8Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Shaheed A AbdulhaqqVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Helen WuVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
John B SchellVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Katherine B HammondVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Jason S ReedVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Alfred W LegasseOregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Michael K AxthelmOregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Byung S ParkVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Aravind AsokanDepartment of Surgery, Duke University, Durham, North Carolina, USA.
Klaus FrühVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Scott G HansenVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Louis J PickerVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Jonah B SachaVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA sacha@ohsu.edu.
Oregon Health & Science University · USOregon National Primate Research Center · USDuke University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Viral Testing CoreU42OD010426 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Samuel Peterson · 2013 to 2026
$6.0M
Understanding Unconventional CD8+ T cell Responses in Protection from HIVR01AI140888 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HANSEN, SCOTT G, SACHA, JONAH B. · 2018 to 2023
$4.4M
A universal MHC-E-restricted T cell vaccine for HIVR01AI117802 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SACHA, JONAH B. · 2015 to 2018
$3.5M
Non-canonical epitope presentation and antigen processing by MHC-ER01AI175459 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Klaus J Fruh, Jonah B. Sacha · 2023 to 2026
$2.8M
NIAID NIH HHS R01 AI117802NIAID NIH HHS R01 AI140888NIAID NIH HHS R01 AI175459NIH HHS P51 OD011092NIH HHS U42 OD010426
6 · The paper itself

Abstract

Major histocompatibility complex E (MHC-E) is a highly conserved nonclassical MHC-Ib molecule that tightly binds peptides derived from leader sequences of classical MHC-Ia molecules for presentation to natural killer cells. However, MHC-E also binds diverse foreign and neoplastic self-peptide antigens for presentation to CD8

Indexed as

AnimalsATP-Binding Cassette TransportersCD8-Positive T-LymphocytesEnzyme InhibitorsHistocompatibility Antigens Class IMacaca mulattaRecombinant ProteinsSAIDS VaccinesSimian Immunodeficiency VirusVaccines, SyntheticATP-Binding Cassette TransportersEnzyme InhibitorsHistocompatibility Antigens Class IRecombinant ProteinsSAIDS Vaccinestransporter associated with antigen processing (TAP)Vaccines, Syntheticmajor histocompatibility complexMHC-ERhCMVT cellstransporter associated with antigen processing

Identifiers

PMID31315990
PMCPMC6744250
OpenAlexW2961204061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.