Evidence map›Paper›PMID 31315851›Full record

Observational studyBMJ open2019

Opt-out bloodborne virus screening: a cross-sectional observational study in an acute medical unit.

Niamh Allen, Collette Faherty, Andre Davies, Anne Lyons, Margarent Scarry, Mary Bohan Keane, Nicola Boyle, Sarah O'Connell, Eithne McCarthy, Deirbhile Keady and 5 more

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Niamh AllenInfectious Diseases, St James' Hospital, Dublin, Ireland.
Collette FahertyMicrobiolgy/ Virology, Galway University Hospitals, Galway, Ireland.
Andre DaviesAcute Medicine Unit, Galway University Hospitals, Galway, Ireland.
Anne LyonsInfectious Diseases, Galway University Hospitals, Galway, Ireland.
Margarent ScarryInfectious Diseases, Galway University Hospitals, Galway, Ireland.
Mary Bohan KeaneHepatology, Galway University Hospitals, Galway, Ireland.
Nicola BoyleInfectious Diseases, Galway University Hospitals, Galway, Ireland.
Sarah O'ConnellInfectious Disease, University Hospital Limerick, Dooradoyle, Ireland.
Eithne McCarthyMicrobiology, Galway University Hospitals, Galway, Ireland.
Deirbhile KeadyMicrobiology, Galway University Hospitals, Galway, Ireland.
Colm BerginDepartment of Genitourinary and Infectious Diseases, St. James's Hospital, Dublin, Ireland.
John LeeHepatology, Galway University Hospitals, Galway, Ireland.
Catherine FlemingInfectious Diseases, Galway University Hospitals, Galway, Ireland.
David GallagherInfectious Diseases, Galway University Hospitals, Galway, Ireland.
Helen TuiteInfectious Diseases, Galway University Hospitals, Galway, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRecent treatment developments for HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV) have greatly improved prognoses. Current screening practices are mainly risk based and are suboptimal. Improved efforts are critically needed to identify persons with these viruses. The aims of this study were to assess the feasibility of an opt-out bloodborne virus (BBV) screening programme in an acute medical unit (AMU) and to describe the prevalence of HIV, HBV and HCV in this population. DESIGN AND

settingThis was a cross-sectional observational study in the AMU of a tertiary referral hospital in Galway, a city in the west of Ireland.

participants1936 patients entered the study; 54% were male, mean age was 53.1 years (SD 19.6). During the study period, all patients attending the AMU aged ≧16 years who were having bloods drawn and who had the ability to verbally consent for an additional blood sample met the inclusion criteria for the study.

resultsOver 44 weeks, 1936/4793 (40.4%) patients consented to BBV panel testing. Diagnosed prevalence rates for HIV, HBV and HCV were 0.5/1000, 2/1000 and 1.5/1000, respectively. There was one HIV-positive result; the patient was already engaged in care. Four patients tested positive for HBV surface antigen; one new diagnosis, one previously lost to follow-up and two already engaged in care. Three patients had active HCV infection; two had been lost to follow-up and are now linked back into services.

conclusionBBV testing uptake of 40.4% is higher than previous studies in AMU settings that used opt-in strategies, but lower than expected, possibly due to not incorporating testing into routine practice. The diagnosed prevalence of HBV is notable as little data currently exist about its prevalence in Ireland. These data are valuable in order to inform further prevention strategies for these infections in low-prevalence settings.

Indexed as

AdultAgedCross-Sectional StudiesFemaleHepatitis BHepatitis CHIV InfectionsHumansIrelandMaleMiddle AgedPatient ParticipationPrevalenceTertiary Care Centersbloodborne viruseshepatitis B virushepatitis C virusopt-out screeningviral hepatitis

Identifiers

PMID31315851
PMCPMC6661585

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.