Evidence map›Paper›PMID 31315679›Full record

ReviewJournal of neuroengineering and rehabilitation2019

Searching for the optimal tDCS target for motor rehabilitation.

Isadora Santos Ferreira, Beatriz Teixeira Costa, Clara Lima Ramos, Pedro Lucena, Aurore Thibaut, Felipe Fregni

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of neuroengineering and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05046145 (Effects of Non-invasive Neuromodulation on Food Desire, Chewing Pattern, Executive Functions and Biochemical Markers of Inflammation and Oxidative Stress), which is not on this map. Cited by 48 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05046145 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Non-invasive Neuromodulation on Food Desire, Chewing Pattern, Executive Functions and Biochemical Markers of Inflammation and Oxidative Stress

TypeinterventionalSponsorUniversidade Federal do PiauíRan2021 to 2022Enrolled36ConditionsCraving, Mastication Disorder, Memory Disorders, Executive DysfunctionArmsspeech therapy for chewing + real tDCS
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. [Localizing target for transcranial electrical stimulation in epilepsy patients combining scalp electroencephalogram and neural computational model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Research progress of tDCS in the treatment of ADHD.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isadora Santos FerreiraNeuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, USA.
Beatriz Teixeira CostaNeuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, USA.
Clara Lima RamosNeuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, USA.
Pedro LucenaNeuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, USA.
Aurore ThibautComa Science Group, GIGA-Consciousness, University of Liege, Liege, Belgium.
Felipe FregniNeuromodulation Center, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, 79/96 13th Street, Charlestown, MA, 02129, USA. ffregni@partners.org.ORCID 0000-0002-4709-8952

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) has been investigated over the years due to its short and also long-term effects on cortical excitability and neuroplasticity. Although its mechanisms to improve motor function are not fully understood, this technique has been suggested as an alternative therapeutic method for motor rehabilitation, especially those with motor function deficits. When applied to the primary motor cortex, tDCS has shown to improve motor function in healthy individuals, as well as in patients with neurological disorders. Based on its potential effects on motor recovery, identifying optimal targets for tDCS stimulation is essential to improve knowledge regarding neuromodulation as well as to advance the use of tDCS in clinical motor rehabilitation. METHODS AND

resultsTherefore, this review discusses the existing evidence on the application of four different tDCS montages to promote and enhance motor rehabilitation: (1) anodal ipsilesional and cathodal contralesional primary motor cortex tDCS, (2) combination of central tDCS and peripheral electrical stimulation, (3) prefrontal tDCS montage and (4) cerebellar tDCS stimulation. Although there is a significant amount of data testing primary motor cortex tDCS for motor recovery, other targets and strategies have not been sufficiently tested. This review then presents the potential mechanisms and available evidence of these other tDCS strategies to promote motor recovery.

conclusionsIn spite of the large amount of data showing that tDCS is a promising adjuvant tool for motor rehabilitation, the diversity of parameters, associated with different characteristics of the clinical populations, has generated studies with heterogeneous methodologies and controversial results. The ideal montage for motor rehabilitation should be based on a patient-tailored approach that takes into account aspects related to the safety of the technique and the quality of the available evidence.

Indexed as

AdultEvoked Potentials, MotorFemaleHumansMaleMotor CortexNervous System DiseasesNeuronal PlasticityTranscranial Direct Current StimulationYoung AdultMotor rehabilitationNon-invasive brain stimulationPain modulationTranscranial direct current stimulation

Identifiers

PMID31315679
PMCPMC6637619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.