Evidence map›Paper›PMID 31315670›Full record

ArticleTrials2019

A prospective randomized double-blind trial of the efficacy of a bilateral lumbar erector spinae block on the 24h morphine consumption after posterior lumbar inter-body fusion surgery.

M B Breebaart, D Van Aken, O De Fré, L Sermeus, N Kamerling, L de Jong, J Michielsen, E Roelant, V Saldien, B Versyck

3 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03825198 phase3unknown statusnot on this map

A Prospective Randomized Double Blind Trial of the Efficacy of a Bilateral Lumbar Erector Spinae Block on the 24h Morphine Consumption After Posterior Lumbar Interbody Fusion Surgery.

TypeinterventionalSponsorDr M. B. BreebaartRan2019 to 2023Enrolled80ConditionsPain, Postoperative, Anaesthesia, Surgery, Nerve BlockArmsErector spinae plane block, Levobupivacaine 0,25%, spine fusion, NaCL 0,9%, Sufentanil
NCT04904575 narecruitingnot on this mapstarted 2022, after this paper: background citation

Erector Spinae Plane Block in Lumbar Spinal Fusion : Double-blind, Randomized Controlled Trial.

TypeinterventionalSponsorClinique Saint Jean, FranceRan2022 to 2026Enrolled130ConditionsLumbar Spinal FusionArmsErector spinae plane block
NCT04925882 nacompletednot on this mapstarted 2022, after this paper: background citation

Erector Spinae Plane Block in Lumbar Release Surgery : Double-blind, Randomized Controlled Trial

TypeinterventionalSponsorClinique Saint Jean, FranceRan2022 to 2022Enrolled100ConditionsHernia Lumbar, Lumbar Canal Stenosis, Spinal Cord CompressionArmsErector spinae plane block
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Efficacy of erector spinae plane block on postoperative pain in patients undergoing lumbar spine surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022
    Trial
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

M B BreebaartDepartment of Anaesthesia, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium. margaretha.breebaart@uza.be.ORCID http://orcid.org/0000-0002-7538-3013
D Van AkenDepartment of Anaesthesia, AZ Klina, Augustijnslei 100, 2930, Brasschaat, Belgium.
O De FréDepartment of Anaesthesia, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.
L SermeusDepartment of Anaesthesia, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.
N KamerlingDepartment of Neurosurgery, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.
L de JongDepartment of Neurosurgery, Klina Hospital Brasschaat, Augustijnslei 100, 2930, Brasschaat, Belgium.
J MichielsenDepartment of Orthopaedics, Antwerp University Hospital, Wilrijkstraat, 10 2650, Edegem, Belgium.
E RoelantClinical Trial Center (CTC), CRC Antwerp, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium.
V SaldienDepartment of Anaesthesia, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.
B VersyckFaculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
Antwerp University Hospital · BEAZ Klina · BEUniversity of Antwerp · BERadboud University Nijmegen · NL

Funding

BARA grant NA
6 · The paper itself

Abstract

backgroundSpine surgery is associated with considerable postoperative pain and can be challenging to treat. A loco-regional technique suitable for spine surgery should cover the dorsal root of the spinal nerves at the levels where surgery is performed. The erector spinae block is a loco-regional technique with promising results and was recently described at the thoracic level. There are no randomized trials of this technique on a lumbar level. This study tests the hypothesis that the 24-h postoperative morphine consumption is significantly lower in patients undergoing posterior lumbar inter-body fusion surgery with a lumbar erector spinae (LUMBES) block when compared with a sham block.

methodsThis prospective randomized double-blind multicenter study will randomly allocate 80 adult patients undergoing elective posterior lumbar inter-body fusion surgery during general anesthesia to one of two groups as follows: (1) bilateral erector spinae block (20 mL 0.25% levobupivacaine) or (2) bilateral sham block (20 mL NaCl 0.9%). Our primary endpoint is 24-h postoperative morphine consumption. Secondary endpoints include 72-h morphine consumption, intraoperative sufentanil dosage, postoperative pain scores at regular time intervals both at rest and during movement, time to first postoperative mobilization, and the Quality of Recovery 40 survey score. DISCUSSION: The LUMBES trial is a pragmatic clinical study that will provide evidence of whether a bilateral lumbar erector spinae block is effective in reducing 24-h postoperative morphine consumption in patients undergoing lumbar inter-body fusion surgery. If this hypothesis is confirmed, this finding could contribute to more widespread implementation of this technique.

trial registrationLocal ethics committee B300201837508, ClinicalTrials.gov identifier: NCT03825198 . Registered on 31 Jan 2019.

Indexed as

AdolescentAdultAgedAnalgesics, OpioidAnesthetics, LocalBack MusclesBack PainBelgiumDouble-Blind MethodFemaleHumansLevobupivacaineLumbar VertebraeMaleMiddle AgedMorphineAnalgesics, OpioidAnesthetics, LocalLevobupivacaineMorphineErector spinae blockLumbar inter-body fusionPostoperative painRegional anesthesia

Identifiers

PMID31315670
PMCPMC6637554
OpenAlexW2961241901

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.